Evidence map›Paper›PMID 32004462›Full record

ArticleCell2020

Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus.

Kenneth Kay, Jason E Chung, Marielena Sosa, Jonathan S Schor, Mattias P Karlsson, Margaret C Larkin, Daniel F Liu, Loren M Frank

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 308 citations in OpenAlex.

  1. Volitional learning promotes theta phase coding in the human hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Drift-diffusion dynamics of hippocampal replay.PLoS computational biology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  13. Review
  14. Planning in the Brain: It's Not What You Think It Is.Annual review of neuroscience · 2026
    Review
  15. Article
  16. The hippocampus as a small-world cognitive map.bioRxiv : the preprint server for biology · 2026
    Article
  17. Article
  18. Article
  19. Top-down regulation of ingestive behavior fragmentation.bioRxiv : the preprint server for biology · 2026
    Article
  20. Article

99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kenneth KayKavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: kk3291@columbia.edu.
Jason E ChungKavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Marielena SosaKavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Jonathan S SchorKavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
Mattias P KarlssonKavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Margaret C LarkinKavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Daniel F LiuKavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Loren M FrankKavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: loren@phy.ucsf.edu.
University of California, San Francisco · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Real-time analysis of memories and decisionsR01MH105174 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDEN, URI TZVI, FRANK, LOREN M · 2014 to 2018
$2.7M
Dynamic Analysis of Neural Plasticity in the Hippocampal CircuitR01MH080283 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRANK, LOREN M · 2007 to 2011
$1.9M
The role of hippocampal replay in memory formation and retrievalR01MH090188 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRANK, LOREN M · 2011 to 2015
$1.9M
Circuit and Behavioral Functions of Hippocampal Subfield CA2F30MH097356 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAY, KENNETH NORMAN · 2012 to 2014
$101k
Howard Hughes Medical InstituteNIGMS NIH HHS T32 GM007618NIMH NIH HHS F30 MH097356NIMH NIH HHS R01 MH080283NIMH NIH HHS R01 MH090188NIMH NIH HHS R01 MH105174
6 · The paper itself

Abstract

Cognitive faculties such as imagination, planning, and decision-making entail the ability to represent hypothetical experience. Crucially, animal behavior in natural settings implies that the brain can represent hypothetical future experience not only quickly but also constantly over time, as external events continually unfold. To determine how this is possible, we recorded neural activity in the hippocampus of rats navigating a maze with multiple spatial paths. We found neural activity encoding two possible future scenarios (two upcoming maze paths) in constant alternation at 8 Hz: one scenario per ∼125-ms cycle. Further, we found that the underlying dynamics of cycling (both inter- and intra-cycle dynamics) generalized across qualitatively different representational correlates (location and direction). Notably, cycling occurred across moving behaviors, including during running. These findings identify a general dynamic process capable of quickly and continually representing hypothetical experience, including that of multiple possible futures.

Indexed as

Action PotentialsAnimalsBehavior, AnimalCognitionDecision MakingHippocampusLocomotionMaleMaze LearningNerve NetNeuronsRatsRats, Long-EvansTheta RhythmCA1CA2CA3decision-makinghippocampusimaginationplace cellsplanningsynchronytheta rhythm

Identifiers

PMID32004462
PMCPMC7126188
OpenAlexW3004187319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.