ArticlePLoS neglected tropical diseases2020
Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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21 citing papers in PubMed, 33 citations in OpenAlex.
- Prevalence of Strongyloides stercoralis in haemodialysis patients in Vienna.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
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- Tricky with Heat and Salt: Soil Factors, Thermotaxis, and Potential for Heat-Saline Agar Trapping ofBiology · 2025Article
- Evaluation of strongyloidiasis prevalence in immunocompromised patients referred to hospitals: a case study of Iran's capital.BMC infectious diseases · 2025Article
- UnderstandingToxicology reports · 2024Review
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- Strongyloides stercoralis Infection in Humans: A Narrative Review of the Most Neglected Parasitic Disease.Cureus · 2023Review
- Overlapping Infection byTropical medicine and infectious disease · 2023Review
- Article
- Transplantation and immigration: Comparing infectious complications and outcomes between foreign-born and US-born kidney transplant recipients in Minnesota.Transplant infectious disease : an official journal of the Transplantation Society · 2023Article
- Evaluation of a Geographic Screening Protocol for Chronic Parasitic Infections Before Kidney Transplant: An Institutional Experience in Minnesota.The American journal of tropical medicine and hygiene · 2022Article
- Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2022Article
- Article
- Modified Nonnutrient Agar Plate Culture for the Diagnosis ofJournal of parasitology research · 2022Article
- Current status of glucocorticoid usage in solid organ transplantation.World journal of transplantation · 2021Review
- Tropical Infections in the Context of Kidney Transplantation in Latin America.The American journal of tropical medicine and hygiene · 2021Review
- Is there autochthonous strongyloidiasis in Spanish children?European journal of pediatrics · 2021Article
- Correction: Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study.PLoS neglected tropical diseases · 2021Article
- Should prospective renal transplant recipients be screened forClinical kidney journal · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere Strongyloides stercoralis infection in kidney transplant recipients is associated with considerable morbidity and mortality, although little is known about the risk factors for such infection. METHODOLOGY/PRINCIPAL
findingsThis was a retrospective, multicenter, case-control study in which we assessed the risk factors for and clinical outcomes of severe S. stercoralis infections in kidney transplant recipients in Brazil. We included 138 kidney transplant recipients: 46 cases and 92 controls. Among the cases, the median number of days from transplantation to diagnosis was 117 (interquartile range [IQR], 73.5-965) and the most common clinical findings were gastrointestinal symptoms (in 78.3%) and respiratory symptoms (in 39.1%), whereas fever and eosinophilia were seen in only 32.6% and 43.5%, respectively. The 30-day all-cause mortality among the cases was 28.3% overall and was significantly higher among the cases of infection occurring within the first three months after transplantation (47% vs. 17.2%, P = 0.04). The independent risk factors were receiving a transplant from a deceased donor (odds ratio [OR] = 6.16, 95% confidence interval [CI] = 2.05-18.5), a history of bacterial infection (OR = 3.04, 95% CI = 1.2-7.5), and a cumulative corticosteroid dose (OR = 1.005, 95% CI = 1.001-1.009). The independent predictors of mortality were respiratory failure (OR = 98.33, 95% CI = 4.46-2169.77) and concomitant bacteremia (OR = 413.00, 95% CI = 4.83-35316.61). CONCLUSIONS/SIGNIFICANCE: Severe S. stercoralis infections are associated with considerable morbidity and mortality after kidney transplantation. In endemic areas, such infection may occur late after transplantation, although it seems to be more severe when it occurs earlier after transplantation. Specific risk factors and clinical manifestations can identify patients at risk, who should receive prophylaxis or early treatment.
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