Evidence map›Paper›PMID 32003974›Full record

ArticleACS nano2020

High-Throughput, High-Resolution Interferometric Light Microscopy of Biological Nanoparticles.

Celalettin Yurdakul, Oguzhan Avci, Alex Matlock, Alexander J Devaux, Maritza V Quintero, Ekmel Ozbay, Robert A Davey, John H Connor, W Clem Karl, Lei Tian and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  3. ACS electrochemistry · 2025
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  6. Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023
    Article
  7. Article
  8. Review
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  10. Virus Detection: From State-of-the-Art Laboratories to Smartphone-Based Point-of-Care Testing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Celalettin YurdakulDepartment of Electrical and Computer Engineering , Boston University , Boston , Massachusetts 02215 , United States.ORCID 0000-0002-1755-4873
Oguzhan AvciDepartment of Electrical and Computer Engineering , Boston University , Boston , Massachusetts 02215 , United States.ORCID 0000-0003-4104-4109
Alex MatlockDepartment of Electrical and Computer Engineering , Boston University , Boston , Massachusetts 02215 , United States.
Alexander J DevauxDepartment of Microbiology and National Infectious Diseases Laboratories , Boston University School of Medicine , Boston , Massachusetts 02118 , United States.
Maritza V QuinteroDepartment of Biochemistry and Structural Biology , University of Texas Health San Antonio , San Antonio , Texas 78229 , United States.
Ekmel OzbayDepartment of Electrical and Electronics Engineering , Bilkent University , 06800 Ankara , Turkey.
Robert A DaveyDepartment of Microbiology and National Infectious Diseases Laboratories , Boston University School of Medicine , Boston , Massachusetts 02118 , United States.
John H ConnorDepartment of Microbiology and National Infectious Diseases Laboratories , Boston University School of Medicine , Boston , Massachusetts 02118 , United States.
W Clem KarlDepartment of Electrical and Computer Engineering , Boston University , Boston , Massachusetts 02215 , United States.
Lei TianDepartment of Electrical and Computer Engineering , Boston University , Boston , Massachusetts 02215 , United States.
M Selim ÜnlüDepartment of Electrical and Computer Engineering , Boston University , Boston , Massachusetts 02215 , United States.
Boston University · USBilkent University · TRThe University of Texas Health Science Center at San Antonio · US

Funding

Virology BSL4 CoreP01AI120943 · NIAID · WASHINGTON UNIVERSITY · PI Gaya K. Amarasinghe · 2016 to 2026
$30.2M
Emerging virus-host cell protein interaction networksR01AI114814 · NIAID · PURDUE UNIVERSITY · PI DAVEY, ROBERT A, LACOUNT, DOUGLAS J. · 2015 to 2019
$3.5M
Recruiting and Retaining URM StudentsR25GM095480 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI OYAJOBI, BABATUNDE OLUKAYODE, WEISS, DAVID S · 2011 to 2021
$3.4M
Genetic probing of residues involved in ebolavirus glycoprotein entryR21AI135517 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CONNOR, JOHN H · 2018 to 2019
$454k
NIAID NIH HHS P01 AI120943NIAID NIH HHS R01 AI114814NIAID NIH HHS R21 AI135517NIGMS NIH HHS R25 GM095480
6 · The paper itself

Abstract

Label-free, visible light microscopy is an indispensable tool for studying biological nanoparticles (BNPs). However, conventional imaging techniques have two major challenges: (i) weak contrast due to low-refractive-index difference with the surrounding medium and exceptionally small size and (ii) limited spatial resolution. Advances in interferometric microscopy have overcome the weak contrast limitation and enabled direct detection of BNPs, yet lateral resolution remains as a challenge in studying BNP morphology. Here, we introduce a wide-field interferometric microscopy technique augmented by computational imaging to demonstrate a 2-fold lateral resolution improvement over a large field-of-view (>100 × 100 μm

Indexed as

High-Throughput Screening AssaysMicroscopy, InterferenceEbola VaccinesNanoparticlesParticle SizeSurface PropertiesViral ProteinsEbola VaccinesViral Proteinsbiosensingcomputational imagingFourier opticsinterference microscopylabel-freenanoparticle detection

Identifiers

PMID32003974
PMCPMC13596749
OpenAlexW3004182719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.