Evidence map›Paper›PMID 32003753›Full record

ArticleAging2020

Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3.

Dong Ji, Guo-Feng Chen, Jin-Cheng Wang, Si-Han Ji, Xue-Wen Wu, Xiao-Jie Lu, Jin-Lian Chen, Jing-Tao Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Circular RNA circLAMC1 Promotes Liver Regeneration by Regulating the miR-138-5p/Gnai2 Axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. A novel hsa_circ_0070963/miR-223-3p/International journal of reproductive biomedicine · 2026
    Article
  4. Review
  5. Role of Circular RNAs in Liver Diseases.International journal of medical sciences · 2026
    Review
  6. Article
  7. Therapeutic Applications of Poly-miRNAs and miRNA Sponges.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Circular RNAs in Liver Diseases.Advances in experimental medicine and biology · 2025
    Review
  10. Review
  11. Review
  12. Crosstalk of ubiquitin system and non-coding RNA in fibrosis.International journal of biological sciences · 2024
    Review
  13. Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy.International journal of molecular sciences · 2023
    Review
  14. Review
  15. CircRNAs: versatile players and new targets in organ fibrosis.Cell communication and signaling : CCS · 2023
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Dong JiSecond Liver Cirrhosis Diagnosis and Treatment Center, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Guo-Feng ChenSecond Liver Cirrhosis Diagnosis and Treatment Center, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Jin-Cheng WangDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Si-Han JiDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xue-Wen WuDepartment of Gastroenterology, Fengxian Hospital, Southern Medical University, Shanghai, China.
Xiao-Jie LuDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jin-Lian ChenDepartment of Gastroenterology, Fengxian Hospital, Southern Medical University, Shanghai, China.
Jing-Tao LiDepartment of Liver Diseases, The Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China.
Nanjing Medical University · CNChinese PLA General Hospital · CNAffiliated Hospital of Shaanxi University of Chinese Medicine · CNShanghai Sixth People's Hospital · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous circular RNA (circRNA) microarray analyses have uncovered an abnormal expression of hsa_circ_0070963 in hepatic stellate cells (HSCs). However, the specific role of hsa_circ_0070963 in liver fibrosis remains unknown. Here, we show that hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3. Moreover, we demonstrated that hsa_circ_0070963 levels were reduced during liver fibrosis while restoring hsa_circ_0070963 levels abolished HSC activation, with a reduction in α-SMA and type I collagen levels both

Indexed as

Gene Expression Regulation, NeoplasticCell LineDNA-Binding ProteinsGenetic Predisposition to DiseaseHepatic Stellate CellsHumansLiver CirrhosisMembrane ProteinsMicroRNAsRNA InterferenceDNA-Binding ProteinsLEMD3 protein, humanMembrane ProteinsMicroRNAsMIR223, humanhepatic stellate cellshsa_circ_0070963LEMD3liver fibrosismiR-223-3p

Identifiers

PMID32003753
PMCPMC7053641
OpenAlexW3004292322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.