ArticleEnvironmental health perspectives2020
Transthyretin-Binding Activity of Complex Mixtures Representing the Composition of Thyroid-Hormone Disrupting Contaminants in House Dust and Human Serum.
Article in Environmental health perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review.Frontiers in endocrinology · 2022Pooled it
- Review of in vitro approaches for assessing the toxicity of chemical stressors across diverse physiological systems.Toxicological sciences : an official journal of the Society of Toxicology · 2026Review
- In Vitro Bioassay Evidence for Chemical Mixture Propagation from the Environment to Humans.Environmental science & technology · 2026Article
- Evaluating the Endocrine-Disrupting and Oxidative Stress Potential of a 50-Component Human-Relevant Complex Chemical Mixture Using In Vitro Tests.Journal of applied toxicology : JAT · 2026Article
- New Docking, Molecular Dynamics, and QSAR Models to Predict Disruption of Human and Rat Transthyretin Function by Per- and Polyfluoroalkyl Substances (PFAS).Chemical research in toxicology · 2026Article
- Review
- Key Messages of the Iodine Deficiency Working Group (AKJ): Maternal Hypothyroxinemia Due to Iodine Deficiency and Endocrine Disruptors as Risks for Child Neurocognitive Development.Geburtshilfe und Frauenheilkunde · 2025Article
- Consensus Modeling Strategies for Predicting Transthyretin Binding Affinity from Tox24 Challenge Data.Chemical research in toxicology · 2025Article
- Spatially dependent tissue distribution of thyroid hormones by plasma thyroid hormone binding proteins.Pflugers Archiv : European journal of physiology · 2025Article
- Profiling the endocrine-disrupting properties of triazines, triazoles, and short-chain PFAS.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin.Archives of toxicology · 2024Article
- Screening the ToxCast Chemical Libraries for Binding to Transthyretin.Chemical research in toxicology · 2024Article
- The pollutant perfluorohexane sulfonate (PFHxS) reduces serum thyroxine but does not alter thyroid action in the postnatal rat brain.Environment international · 2024Article
- Spatially Dependent Tissue Distribution of Thyroid Hormones by Plasma Thyroid Hormone Binding Proteins.bioRxiv : the preprint server for biology · 2024Article
- Toxicity Screening of Fungal Extracts and Metabolites, Xenobiotic Chemicals, and Indoor Dusts with In Vitro and Ex Vivo Bioassay Methods.Pathogens (Basel, Switzerland) · 2024Article
- A 2024 inventory of test methods relevant to thyroid hormone system disruption for human health and environmental regulatory hazard assessment.Open research Europe · 2024Review
- Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review.Nutrients · 2023Article
- Electrochemical Oxidation for Treatment of PFAS in Contaminated Water and Fractionated Foam-A Pilot-Scale Study.ACS ES&T water · 2023Article
- A minimal human physiologically based kinetic model of thyroid hormones and chemical disruption of plasma thyroid hormone binding proteins.Frontiers in endocrinology · 2023Article
- Mixture Risk Assessment of Complex Real-Life Mixtures-The PANORAMIX Project.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHouse dust contains many organic contaminants that can compete with the thyroid hormone (TH) thyroxine (
objectivesOur aims were to determine the TTR-binding potency for contaminant mixtures as found in house dust, maternal serum, and infant serum; to study whether the TTR-binding potency of the mixtures follows the principle of concentration addition; and to extrapolate the
methodsTwenty-five contaminants were tested for their
resultsThe TTR-binding potency of the mixtures was well predicted by concentration addition. The DISCUSSION: The relatively low estimated inhibition levels at median exposure levels may explain why no relationship between exposure to TTR-binding compounds and circulating
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.