ArticleJournal of veterinary internal medicine2020
Thoracolumbar meningeal fibrosis in pugs.
Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Spinal arachnoid diverticula and constrictive myelopathy in dogs: different conditions or a spectrum of spinal meningeal disease in veterinary and human medicine?Frontiers in veterinary science · 2026Review
- Prevalence and breed predisposition for spinal diseases in pugs and French bulldogs.The Veterinary record · 2025Article
- Case Report: Long-term surgical outcomes in pug dogs with articular facet dysplasia-associated thoracolumbar myelopathies.Frontiers in veterinary science · 2025Article
- Thoracolumbar myelopathies in pug dogs.Journal of veterinary internal medicine · 2023Article
- Article
- Surgical techniques used in the management of intra-arachnoid diverticula in dogs across four referral centres and their immediate outcome.The Journal of small animal practice · 2022Article
- Retrospective evaluation of surgical outcomes after closure of durotomy in eight dogs affected by spinal subarachnoid diverticulum.Open veterinary journal · 2021Article
- Thoracolumbar meningeal fibrosis in pugs.Journal of veterinary internal medicine · 2020Article
- Mutations in the CYP27B1 gene cause vitamin D dependent rickets in pugs.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
Abstract
backgroundThoracolumbar myelopathies associated with spinal cord and vertebral column lesions, with a similar clinical phenotype, but different underlying etiologies, occur in pugs.
objectivesTo further characterize the clinical and neuropathological characteristics of pugs with longstanding thoracolumbar myelopathy. ANIMALS: Thirty client-owned pure-bred pugs with a history of more than a month of ataxia and paresis of the pelvic limbs, suggesting a myelopathy localized to the thoracolumbar spinal cord, were included in the study.
methodsProspective clinicopathological study. Included pugs underwent a complete neurological examination and gross and histopathologic postmortem studies with focus on the spinal cord. Computed tomography (n = 18), magnetic resonance imaging (n = 17), and cerebrospinal fluid analysis (n = 27) were performed before or immediately after death.
resultsTwenty male and 10 female pugs had a median age at clinical onset of 84 months (interquartile range, 66-96). Affected pugs presented with a progressive clinical course and 80% were incontinent. There was circumferential meningeal fibrosis with concomitant focal, malacic, destruction of the neuroparenchyma in the thoracolumbar spinal cord in 24/30 pugs. Vertebral lesions accompanied the focal spinal cord lesion, and there was lympho-histiocytic inflammation associated or not to the parenchymal lesion in 43% of the pugs. CONCLUSIONS AND CLINICAL IMPORTANCE: Meningeal fibrosis with associated focal spinal cord destruction and neighboring vertebral column lesions were common findings in pugs with long-standing thoracolumbar myelopathy.
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