Evidence map›Paper›PMID 32002798›Full record

ArticleJournal of nephrology2021

Screening strategies for the diagnosis of asymptomatic Leishmania infection in dialysis patients as a model for kidney transplant candidates.

Giorgia Comai, Alessandra Mistral De Pascali, Marco Busutti, Silvia Morini, Margherita Ortalli, Diletta Conte, Maria Carla Re, Gaetano La Manna, Stefania Varani

Open access · hybridAbstract read
In one paragraph

Article in Journal of nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Kidney complications of parasitic diseases.Nature reviews. Nephrology · 2022
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Giorgia Comai *Department of Experimental, Diagnostic and Specialty Medicine (DIMES)-Nephrology, Dialysis and Renal Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Via G. Massarenti 9 (Pad. 15), 40138, Bologna, Italy. giorgia.comai@aosp.bo.it.
Alessandra Mistral De Pascali *Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Marco BusuttiDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES)-Nephrology, Dialysis and Renal Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Via G. Massarenti 9 (Pad. 15), 40138, Bologna, Italy.
Silvia MoriniUnit of Clinical Microbiology, Regional Reference Centre for Microbiological Emergencies (CRREM), St. Orsola-Malpighi University Hospital, Bologna, Italy.
Margherita OrtalliUnit of Clinical Microbiology, Regional Reference Centre for Microbiological Emergencies (CRREM), St. Orsola-Malpighi University Hospital, Bologna, Italy.
Diletta ConteDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES)-Nephrology, Dialysis and Renal Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Via G. Massarenti 9 (Pad. 15), 40138, Bologna, Italy.
Maria Carla ReDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Gaetano La MannaDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES)-Nephrology, Dialysis and Renal Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Via G. Massarenti 9 (Pad. 15), 40138, Bologna, Italy.
Stefania VaraniDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
University of Bologna · ITPoliclinico S.Orsola-Malpighi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite being considered a tropical disease, visceral leishmaniasis (VL) caused by L. infantum is also endemic in the Mediterranean Europe and represents an increasing cause of morbidity and mortality in solid organ transplant (SOT) recipients. VL occurring in kidney transplant recipients is a severe event, often worsening the renal damage and leading to poor outcome. It is believed that most of VL cases in transplant recipients are caused by reactivation of a pre-existent, dormant leishmanial infection induced by the immunosuppressive drugs. Nevertheless, the prevalence of asymptomatic Leishmania infection in candidates to kidney transplant residing in or visiting endemic areas is unknown. As L. infantum is highly circulating in northeastern Italy, we aimed to examine the occurrence of this parasitic infection in 119 dialysis patients living in the mentioned area, 71 of whom were potential candidates to kidney transplant. By employing a combination of sensitive serological and molecular methods, we observed a prevalence of 15.9% asymptomatic Leishmania infection in the study cohort. This finding emphasizes the need of further evaluating potential screening strategies for Leishmania infection in solid organ transplant candidates residing in or visiting endemic areas.

Indexed as

Kidney TransplantationLeishmania infantumLeishmaniasisLeishmaniasis, VisceralHumansRenal DialysisDialysis treatmentEnd stage renal diseaseLeishmania infantumMolecular methodsSerological methods

Identifiers

PMID32002798
PMCPMC7881953
OpenAlexW3003890719

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.