ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020
The role of clivus length and cranial base flexion angle in basilar invagination and Chiari malformation pathophysiology.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The management of Chiari malformation type 1 and syringomyelia in children: a review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Diagnostic Performance and Reproducibility of Odontoid Retroflexion Angle and Posterior Basion-C2 Line in Type II Basilar Invagination.Medeniyet medical journal · 2026Article
- A test of the ArchaicEvolution, medicine, and public health · 2025Article
- The role of clivus and atlanto-occipital lateral mass height in basilar invagination with or without atlas occipitalization.Neurosurgical review · 2024Article
- Evaluation and Treatment of Patients with Small Posterior Cranial Fossa and Chiari Malformation, Types 0 and 1.Advances and technical standards in neurosurgery · 2024Article
- Coronavirus disease 2019-associated persistent cough and Chiari malformation type I resulting in acute respiratory failure: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- A Novel Craniocervical Junction Compression Severity Index-Based Grading System for Multidirectional Quantification of the Biomechanics at Foramen Magnum of Chiari Malformation Type I.Journal of neurological surgery. Part B, Skull base · 2023Article
- Onset of Chiari type 1 malformation: insights from a small series of intrauterine MR imaging cases.Neuroradiology · 2023Article
- Use of deep learning in the MRI diagnosis of Chiari malformation type I.Neuroradiology · 2022Article
- Craniofacial and Craniocervical Features in Cartilage-Hair Hypoplasia: A Radiological Study of 17 Patients and 34 Controls.Frontiers in endocrinology · 2021Article
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2 authors.
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Abstract
backgroundThe craniovertebral junction is an anatomically well-defined transitional zone located between the skull and the cervical spine. Multiple malformations can affect this region with the most prominent being basilar invagination (BI) and Chiari malformation (CM). Despite numerous studies, the origin, pathophysiology, and classification of these pathologies remain controversial. The objective of this study was to evaluate the implication of cranial base flexion angle and clivus length in the development of these conditions.
methodsMidline tomography and magnetic resonance imaging of normal subjects and patients diagnosed with BI (types I and II) and Chiari malformation were evaluated. A craniometric study of the skull base was performed. Linear and angular measurements were used for comparisons between groups.
results109 images from patients with craniovertebral junction malformation and controls were evaluated. Seventeen had BI-I, 26 had BI-II, 36 had CM, and 30 were normal subjects. Demographic data for the two groups were not significantly different. Craniometric analysis of images revealed a gradation in linear and angular variables from controls to CM, BI-I, and BI-II patients. Clivus length was significantly smaller in BI-II patients compared with other groups, while basal angle was greater. Moderate or strong correlations were noted among all variables analyzed.
conclusionData suggest that clivus length and basal angle may play a role in pathophysiology of BI and CM.
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