Evidence map›Paper›PMID 32002683›Full record

ArticleJournal of materials science. Materials in medicine2020

β-cyclodextrin coating: improving biocompatibility of magnetic nanocomposites for biomedical applications.

Mariela Agotegaray, María Gabriela Blanco, Adrián Campelo, Elba García, Roberto Zysler, Virginia Massheimer, María José De Rosa, Verónica Lassalle

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mariela AgotegarayDepartamento de Química, Instituto de Química del Sur (INQUISUR-CONICET)-UNS, Universidad Nacional del Sur, Bahía Blanca, Argentina. magotegaray@uns.edu.ar.ORCID http://orcid.org/0000-0002-0206-306X
María Gabriela BlancoDpto. de Biología, Bioquímica y Farmacia, Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB-CONICET)-UNS, Lab. de Neurobiología de Invertebrados, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Adrián CampeloDpto. de Biología, Bioquímica y Farmacia,Instituto de Investigaciones Biológicas y Biomédicas del Sur (INBIOSUR-CONICET)-UNS, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Elba GarcíaDepartamento de Química, Instituto de Química del Sur (INQUISUR-CONICET)-UNS, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Roberto ZyslerCONICET-Centro Atómico Bariloche, Instituto Balseiro, S.C. de Bariloche, Río Negro, Argentina.
Virginia MassheimerDpto. de Biología, Bioquímica y Farmacia,Instituto de Investigaciones Biológicas y Biomédicas del Sur (INBIOSUR-CONICET)-UNS, Universidad Nacional del Sur, Bahía Blanca, Argentina.
María José De RosaDpto. de Biología, Bioquímica y Farmacia, Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB-CONICET)-UNS, Lab. de Neurobiología de Invertebrados, Universidad Nacional del Sur, Bahía Blanca, Argentina. mjderosa@criba.edu.ar.
Verónica LassalleDepartamento de Química, Instituto de Química del Sur (INQUISUR-CONICET)-UNS, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARUniversidad Nacional del Sur · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role Beta-cyclodextrin (βCD) on improving biocompatibility on healthy cellular and animal models was studied upon a formulation obtained from the development of a simple coating procedure. The obtained nanosystems were thoroughly characterized by FTIR, TGA, atomic absorption spectroscopy, dynamic light scattering and zeta potential, TEM/HR-TEM and magnetic properties. βCD might interact with the magnetic core through hosting OA. It is feasible that the nanocomposite is formed by nanoparticles of MG@OA dispersed in a βCD matrix. The evaluation of βCD role on biocompatibility was performed on two healthy models. To this end, in vivo studies were carried out on Caenorhabditis elegans. Locomotion and progeny were evaluated after exposure animals to MG, MG@OA, and MG@OA-βCD (10 to 500 µg/mL). The influence of βCD on cytotoxicity was explored in vitro on healthy rat aortic endothelial cells, avoiding alteration in the results derived from the use of transformed cell lines. Biological studies demonstrated that βCD attaching improves MG biocompatibility.

Indexed as

MagneticsMaterials TestingAnimalsbeta-CyclodextrinsCaenorhabditis elegansCell SurvivalDose-Response Relationship, DrugEndothelial CellsEndothelium, VascularMolecular StructureNanocompositesRatsRats, WistarSurface Propertiesbeta-Cyclodextrinsbetadex

Identifiers

PMID32002683
OpenAlexW3003424993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.