ArticleClinical oral investigations2020
Association of Streptococcus mutans collagen binding genes with severe childhood caries.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- TheApplied and environmental microbiology · 2026Article
- Evaluation of Streptococcus mutans strains possessing genes encoding collagen-binding proteins in the Japanese population.BMC oral health · 2025Article
- Cell wall glycosyltransferase ofInfection and immunity · 2025Article
- Potential correlation between dental caries and intracranial aneurysm: an innovative prognostic marker for intracranial aneurysm development.Frontiers in neurology · 2025Article
- Clinical characteristics of children and guardians possessing CBP-positive Streptococcus mutans strains: a cross-sectional study.Scientific reports · 2022Article
- Risk Assessment of Cnm-PositiveFrontiers in neurology · 2022Article
- Genotypic and phenotypic characterization ofIranian journal of microbiology · 2021Article
- Oral Carriage ofStroke · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAn important factor in the assessment of caries risk is the presence of specific oral microflora, especially Streptococcus mutans. Some S. mutans strains possess proteins capable of binding collagen, such as the Cnm and Cbm proteins. The aim is to determine the presence of S. mutans strains carrying collagen binding proteins in a group of subjects with severe early childhood caries (S-ECC). MATERIALS AND
methodsS. mutans strains isolated from 15 S-ECC children were analyzed for collagen binding domains (cbd) of the cnm (cbd/cnm) and cbm (cbd/cbm) genes and their ability to bind to collagen.
resultsS. mutans strains positive for cbd/cnm or cbd/cbm were only found in 3 subjects with the most severe caries profile, with one subject having both cbd/cnm and cbd/cbm, and the other two with one of each. cnm/cbm-positive S. mutans strains bound to collagen substrate more avidly compared with negative S. mutans strains from each of the three groups.
conclusionsOur findings of an association between the presence of the collagen binding domains of the cnm/cbm genes in plaque S. mutans and the most aggressive form of caries profile in children offer a potential strategy to identify an individual's risk for caries progression. Our study should be replicated in other settings and communities in longitudinal and longer-term studies. CLINICAL RELEVANCE: Our data offer a potential tool in the caries risk management and assessment in children.
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