ReviewCurrent gastroenterology reports2020
Sleep and Fatigue in IBD: an Unrecognized but Important Extra-intestinal Manifestation.
Review in Current gastroenterology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- Fatigue in Inflammatory Bowel Disease: The Role of Drug Therapy Within a Holistic Management Framework.Drugs · 2026Review
- Fatigue burden and patient attribution across remission states in inflammatory bowel disease: a longitudinal cohort study.Crohn's & colitis 360 · 2026Article
- Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis.Frontiers in immunology · 2026Article
- Clinical Response and Improvement of the Quality of Life, Fatigue, Mood, and Sleep Disturbances During Vedolizumab Induction Therapy in Polish Patients With Moderate-to-Severe Ulcerative Colitis or Crohn's Disease.Canadian journal of gastroenterology & hepatology · 2026Observational
- Fatigue in inflammatory bowel disease: Prevalence, risk factors, assessment, outcomes, and management.World journal of gastrointestinal pathophysiology · 2025Review
- The Substantial Role of Sleep, Stress, and Physical Activity in Persistent High Levels of Fatigue in Patients With Inflammatory Bowel Disease: A Longitudinal Trajectory Study.Journal of Crohn's & colitis · 2025Article
- Fatigue in Patients with Inflammatory Bowel Disease in Remission One Year After Diagnosis (the IBSEN III Study).Journal of Crohn's & colitis · 2025Article
- US and European Patient and Health Care Professional Perspectives on Fatigue in Ulcerative Colitis and Crohn's Disease: Results From the Communicating Needs and Features of Inflammatory Bowel Disease Experiences Survey.Crohn's & colitis 360 · 2025Article
- Trends in Mortality Due to Inflammatory Bowel Disease in the United States: A CDC WONDER Database Analysis (1999-2020).Digestive diseases and sciences · 2025Review
- Management of Fatigue in Inflammatory Bowel Disease: A Narrative Review.International journal of general medicine · 2025Review
- Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study.Therapeutic advances in gastroenterology · 2025Article
- Greater Fatigue and Reduced Neurocognitive Speed With Symptomatic Crohn's Disease.Crohn's & colitis 360 · 2025Article
- Prevalence and risk factors of sleep disorders in inflammatory bowel disease: a cross-sectional study.International journal of colorectal disease · 2024Article
- Shared Pathophysiology of Inflammatory Bowel Disease and Psoriasis: Unraveling the Connection.Cureus · 2024Review
- Saffron as a Promising Therapy for Inflammatory Bowel Disease.Nutrients · 2024Review
- Post-traumatic stress disorder symptoms are frequent among inflammatory bowel disease patients of South Asian descent-A case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Article
- The impact of the COVID-19 pandemic on the mental health of patients diagnosed with inflammatory bowel diseases.Journal of medicine and life · 2023Article
- Fatigue in Patients with Newly Diagnosed Inflammatory Bowel Disease: Results from a Prospective Inception Cohort, the IBSEN III Study.Journal of Crohn's & colitis · 2023Article
- Economic Burden of Fatigue in Inflammatory Bowel Disease.Crohn's & colitis 360 · 2023Article
- Relationship between the Biological Clock and Inflammatory Bowel Disease.Clocks & sleep · 2023Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe bidirectional relationship between sleep disorders and inflammatory bowel disease (IBD) has gained considerable attention in recent years. It has been suggested that poor sleep and fatigue are extra-intestinal manifestations of IBD. This review reports recent studies exploring subjective and objective assessments of sleep in the adult IBD population. RECENT
findingsIn ulcerative colitis patients, poor sleep has been independently linked to depression and poorer IBD-related quality of life. Using home polysomnography, IBD patients were shown to have less rapid eye movement sleep and Crohn's patient had increased lighter sleep. A study utilizing surveys assessing circadian rhythms described circadian misalignment in IBD patients and reported that circadian misalignment in Crohn's disease was associated with a more aggressive disease phenotype. The use of biologics may improve sleep disturbances in patients with IBD. Translational and clinical studies have reported that disturbances in sleep quality are linked to intestinal inflammation and a heighted systemic immune response. IBD patients appear to have disturbed sleep. Poor sleep is also suggested as a marker for subclinical disease activity. Recent studies have suggested circadian misalignment in IBD patients, and future studies are needed to assess these clinical implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.