ArticleEuropean radiology2020
Can breast MRI accurately exclude malignancy in mammographic architectural distortion?
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The diagnostic performance of ultrafast MRI to differentiate benign from malignant breast lesions: a systematic review and meta-analysis.European radiology · 2024Pooled it
- 조영증강 유방촬영술: 현재의 임상적 활용과 미래 방향에 대한 종합적 고찰.Journal of the Korean Society of Radiology · 2025Review
- The value of intratumoral and peritumoral ultrasound radiomics model constructed using multiple machine learning algorithms for non-mass breast cancer.Scientific reports · 2025Article
- Contrast-enhanced mammography in the management of breast architectural distortions and avoidance of unnecessary biopsies.Breast cancer (Tokyo, Japan) · 2024Article
- A comprehensive analysis of imaging features and clinical characteristics to differentiate malignant from non-malignant mammographic architectural distortion.Gland surgery · 2024Article
- Value of mammographic microcalcifications and MRI-enhanced lesions in the evaluation of residual disease after neoadjuvant therapy for breast cancer.Quantitative imaging in medicine and surgery · 2023Article
- The value of MRI for downgrading of breast suspicious lesions detected on ultrasound.BMC medical imaging · 2023Article
- Identification and diagnosis of mammographic malignant architectural distortion using a deep learning based mask regional convolutional neural network.Frontiers in oncology · 2023Article
- Digital tomosynthesis spot view in architectural distortions: outcomes in management and radiation dose.La Radiologia medica · 2023Article
- Differentiation of Benign and Malignant Breast Lesions Using ADC Values and ADC Ratio in Breast MRI.Diagnostics (Basel, Switzerland) · 2022Article
- Architectural distortion outcome: digital breast tomosynthesis-detected versus digital mammography-detected.La Radiologia medica · 2022Article
- Magnetic resonance imaging in diagnosis of indeterminate breast (BIRADS 3 & 4A) in a general population.Insights into imaging · 2021Article
- Radial Scar: a management dilemma.La Radiologia medica · 2021Review
- Diffusion-weighted Imaging Allows for Downgrading MR BI-RADS 4 Lesions in Contrast-enhanced MRI of the Breast to Avoid Unnecessary Biopsy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the diagnostic accuracy of problem-solving breast magnetic resonance imaging (MRI) in excluding malignancy in a cohort of patients diagnosed with mammographic architectural distortion (MAD).
methodsThe Institutional Review Board approved the study. Imaging database with 40,245 breast MRIs done between January 2008 and September 2018 was retrospectively reviewed. The study included all exams considered problem-solving MRI for MAD. Two radiologists reviewed the imaging data. Outcome was determined by the pathology results of biopsy/surgical excision or at least 1 year of clinical and radiological follow-up. Predictors for malignancy were examined, and appropriate statistical tests were applied.
resultsOne hundred seventy-five patients (median age 53 years) fulfilled the inclusion criteria and formed the study cohort. No cancers were diagnosed in 106 patients with a negative MRI. Out of 69 women with positive MRI findings, 48 (70%) had benign outcome defined either by pathology result or by negative follow-up, and 21 (30%) yielded malignancy. Malignancy was significantly associated with positive MRI (p < 0.001) and older age (p = 0.014). Falsely positive MRIs were frequently found in women with radial scars. The sensitivity, specificity, negative predictive value, positive predictive value, and overall accuracy of breast MRI were 100% (95% CI 84 to 100%), 68% (CI 61 to 76%), 100% (CI 95 to 100%), 30% (CI 26 to 36%), and 73% (95% CI 66-79), respectively.
conclusionA negative breast MRI in patients with MAD was reliable in excluding malignancy in this cohort and may have a role as a precision medicine tool for avoiding unnecessary interventions. KEY POINTS: • MRI shows a high negative predictive value in MAD cases. • MRI displays low accuracy in differentiating malignancy from RS. • MRI is a reliable non-invasive method to exclude malignancy in women with mammographic architectural distortion, potentially avoiding unnecessary biopsies and surgeries.
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