ArticleEuropean radiology2020
Normative brain volume reports may improve differential diagnosis of dementing neurodegenerative diseases in clinical practice.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Commercial volumetric MRI reporting tools in multiple sclerosis: a systematic review of the evidence.Neuroradiology · 2023Pooled it
- Technical and clinical validation of commercial automated volumetric MRI tools for dementia diagnosis-a systematic review.Neuroradiology · 2021Pooled it
- Clinical validation pipeline of a deep learning model for segmenting and quantifying intracranial and ventricular volumes on computed tomography.Scientific reports · 2026Article
- SynPoC: a high-quality generative diffusion model for transforming ultra-low-field point-of-care MRI using high-field MRI representations.Scientific reports · 2026Article
- Associations Between Myopia and Brain Volumes: An Observational and Genetic Analysis.Investigative ophthalmology & visual science · 2025Observational
- Longitudinal automated brain volumetry versus expert visual assessment of atrophy progression on MRI: an exploratory study.Scientific reports · 2025Article
- Reply.AJNR. American journal of neuroradiology · 2025Article
- A Comparison of the Brain Parameters of Thais with Normal Cognition, Mild Cognitive Impairment, and Dementia.Brain sciences · 2025Article
- Automated Volumetric Software in Dementia: Help or Hindrance to the Neuroradiologist?AJNR. American journal of neuroradiology · 2024Article
- Normal cohorts in automated brain atrophy estimation: how many healthy subjects to include?European radiology · 2024Article
- Voxel-based morphometry in single subjects without a scanner-specific normal database using a convolutional neural network.European radiology · 2024Article
- Searching for the grail: may machine learning be a road to clinical use of brain MRI segmentation?European radiology · 2024Article
- Removing outliers from the normative database improves regional atrophy detection in single-subject voxel-based morphometry.Neuroradiology · 2024Article
- Article
- Modern Methods of Diagnostics and Treatment of Neurodegenerative Diseases and Depression.Diagnostics (Basel, Switzerland) · 2023Review
- Exploring Genetic and Neural Risk of Specific Reading Disability within a Nuclear Twin Family Case Study: A Translational Clinical Application.Journal of personalized medicine · 2023Article
- Quantification of amyloid PET for future clinical use: a state-of-the-art review.European journal of nuclear medicine and molecular imaging · 2022Review
- Comparing two artificial intelligence software packages for normative brain volumetry in memory clinic imaging.Neuroradiology · 2022Article
- Impact of defacing on automated brain atrophy estimation.Insights into imaging · 2022Article
- Impact of normative brain volume reports on the diagnosis of neurodegenerative dementia disorders in neuroradiology: A real-world, clinical practice study.Frontiers in aging neuroscience · 2022Article
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12 authors.
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Abstract
objectivesNormative brain volume reports (NBVRs) are becoming more and more available for the workup of dementia patients in clinical routine. However, it is yet unknown how this information can be used in the radiological decision-making process. The present study investigates the diagnostic value of NBVRs for detection and differential diagnosis of distinct regional brain atrophy in several dementing neurodegenerative disorders.
methodsNBVRs were obtained for 81 consecutive patients with distinct dementing neurodegenerative diseases and 13 healthy controls (HC). Forty Alzheimer's disease (AD; 18 with dementia, 22 with mild cognitive impairment (MCI), 11 posterior cortical atrophy (PCA)), 20 frontotemporal dementia (FTD), and ten semantic dementia (SD) cases were analyzed, and reports were tested qualitatively for the representation of atrophy patterns. Gold standard diagnoses were based on the patients' clinical course, FDG-PET imaging, and/or cerebrospinal fluid (CSF) biomarkers following established diagnostic criteria. Diagnostic accuracy of pattern representations was calculated.
resultsNBVRs improved the correct identification of patients vs. healthy controls based on structural MRI for rater 1 (p < 0.001) whereas the amount of correct classifications was rather unchanged for rater 2. Correct differential diagnosis of dementing neurodegenerative disorders was significantly improved for both rater 1 (p = 0.001) and rater 2 (p = 0.022). Furthermore, interrater reliability was improved from moderate to excellent for both detection and differential diagnosis of neurodegenerative diseases (κ = 0.556/0.894 and κ = 0.403/0.850, respectively).
conclusionNBVRs deliver valuable and observer-independent information, which can improve differential diagnosis of neurodegenerative diseases. KEY POINTS: • Normative brain volume reports increase detection of neurodegenerative atrophy patterns compared to visual reading alone. • Differential diagnosis of regionally distinct atrophy patterns is improved. • Agreement between radiologists is significantly improved from moderate to excellent when using normative brain volume reports.
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