ArticleEuropean radiology2020
Hepatic hemangioendothelioma: CT, MR, and FDG-PET-CT in 67 patients-a bi-institutional comprehensive cancer center review.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 29 citations in OpenAlex.
- Microwave ablation and transcatheter arterial chemoembolization for hepatic epithelioid hemangioendothelioma two case reports with literature review.Discover oncology · 2026Article
- Quantitative assessment of multi-phase contrast-enhanced CT features in hepatic epithelioid hemangioendothelioma.Journal of gastrointestinal oncology · 2025Article
- Hepatic epithelioid hemangioendothelioma managed with minimally invasive surgery: A case report.World journal of clinical cases · 2025Article
- Comparison of clinical and MRI features of hepatic angiosarcoma and epithelioid hemangioendothelioma.Abdominal radiology (New York) · 2025Article
- Proposed diagnostic and prognostic markers of primary malignant hepatic vascular neoplasms.Diagnostic pathology · 2024Article
- MRI and PET/CT of multiple primary hepatic angiosarcomas in 25-year-old man: A case report.Journal of clinical imaging science · 2024Article
- Retiform hemangioendothelioma of the breast in a man withSurgical case reports · 2023Article
- CT and MRI features of hepatic epithelioid haemangioendothelioma: a multi-institutional retrospective analysis of 15 cases and a literature review.Insights into imaging · 2023Article
- Hepatic epithelioid hemangioendothelioma: pitfalls in the treatment of a rare liver malignancy.Translational gastroenterology and hepatology · 2023Article
- MRI appearances of hepatic epithelioid hemangioendothelioma: a retrospective study of 57 patients.Insights into imaging · 2022Article
- Clinical characteristics and CT features of hepatic epithelioid haemangioendothelioma and comparison with those of liver metastases.Insights into imaging · 2022Article
- Novel and Specific MRI Features Indicate the Clinical Features of Patients With Rare Hepatic Tumor Epithelioid Hemangioendothelioma.Frontiers in oncology · 2022Article
- Hepatic epithelioid hemangioendothelioma simulating liver metastasis: A case report.Annals of medicine and surgery (2012) · 2021Article
- New insights into the pathophysiology and clinical care of rare primary liver cancers.JHEP reports : innovation in hepatology · 2021Review
- Advancing the diagnosis of epithelioid hemangioendothelioma byAmerican journal of nuclear medicine and molecular imaging · 2021Article
- Epithelioid hemangioendothelioma: evaluation byAmerican journal of nuclear medicine and molecular imaging · 2021Article
- Indocyanine green and its nanosynthetic particles for the diagnosis and treatment of hepatocellular carcinoma.American journal of translational research · 2020Review
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8 authors at 2 institutions in 1 country.
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Abstract
objectiveTo evaluate the imaging features of hepatic epithelioid hemangioendothelioma (HEH) on multiphasic CT, MR, and FDG-PET-CT.
methodsBi-institutional review identified 67 adults (mean age, 47 years; 23 M/44 F) with pathologically proven HEH and pretreatment multiphasic CT (n = 67) and/or MR (n = 30) and/or FDG-PET-CT (n = 13).
resultsHEHs were multifocal in 88% (59/67). Mean size of the dominant mass was 4.1 cm (range, 1.4-19 cm). The tumors were located in the peripheral, subcapsular regions of the liver in 96% (64/67). Capsular retraction was present in 81% (54/67 cases) and tumors were coalescent in 61% (41/67). HEH demonstrated peripheral ring enhancement on arterial phase imaging in 33% (21/64) and target appearance on the portal venous phase in 69% (46/67). Persistent peripheral enhancement on the delayed phase was seen in 49% (31/63). On MR, multilayered target appearance was seen on the T2-weighted sequences in 67% (20/30) and on the diffusion-weighted sequences in 61% (11/18). Target appearance on hepatobiliary phase of MRI was seen in 57% (4/7). On pre-therapy FDG-PET-CT, increased FDG uptake above the background liver parenchyma was seen in 62% (8/13).
conclusionHEHs typically manifest as multifocal, coalescent hepatic nodules in peripheral subcapsular location, with associated capsular retraction. Peripheral arterial ring enhancement and target appearance on portal venous phase are commonly seen on CT. Similarly, multilayered target appearance correlating with its histopathological composition is typically seen on multiple sequences of MR including T2-weighted, diffusion-weighted, and dynamic contrast-enhanced multiphasic MR. KEY POINTS: • Hepatic epithelioid hemangioendotheliomas manifest on CT and MR as multifocal, coalescent hepatic nodules in peripheral subcapsular location, with associated capsular retraction. • Enhancement pattern on contrast-enhanced CT and MR can vary but peripheral ring enhancement on arterial phase and target appearance on portal venous phase are commonly seen. • Retrospective two-center study showed that cross-sectional imaging may help in the diagnosis.
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