Evidence map›Paper›PMID 32002583›Full record

Trial reportWorld journal of surgery2020

Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomized Controlled Trial.

Hosseinali Khalili, Rebecka Ahl, Shahram Paydar, Gabriel Sjolin, Yang Cao, Hossein Abdolrahimzadeh Fard, Amin Niakan, Kamil Hanna, Bellal Joseph, Shahin Mohseni

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  16. Morbidity prediction in conservatively managed rib fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Hosseinali KhaliliDepartment of Neurosurgery, Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Rebecka AhlDepartment of Surgery, Karolinska University Hospital, Stockholm, Sweden.
Shahram PaydarTrauma Research Center, Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Gabriel SjolinDepartment of Surgery, Orebro University Hospital, 701 85, Örebro, Sweden.
Yang CaoClinical Epidemiology and Biostatistics, School of Medical Sciences, Orebro University, 701 82, Örebro, Sweden.
Hossein Abdolrahimzadeh FardDepartment of Surgery, Karolinska University Hospital, Stockholm, Sweden.
Amin NiakanDepartment of Neurosurgery, Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Kamil HannaDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Bellal JosephDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Shahin MohseniSchool of Medical Sciences, Orebro University, 702 81, Örebro, Sweden. mohsenishahin@yahoo.com.
Örebro University · SENamazi Hospital · IRShiraz University of Medical Sciences · IRUniversity of Arizona · USÖrebro University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObservational studies have demonstrated improved outcomes in TBI patients receiving in-hospital beta-blockers. The aim of this study is to conduct a randomized controlled trial examining the effect of beta-blockers on outcomes in TBI patients.

methodsAdult patients with severe TBI (intracranial AIS ≥ 3) were included in the study. Hemodynamically stable patients at 24 h after injury were randomized to receive either 20 mg propranolol orally every 12 h up to 10 days or until discharge (BB+) or no propranolol (BB-). Outcomes of interest were in-hospital mortality and Glasgow Outcome Scale-Extended (GOS-E) score on discharge and at 6-month follow-up. Subgroup analysis including only isolated severe TBI (intracranial AIS ≥ 3 with extracranial AIS ≤ 2) was carried out. Poisson regression models were used.

resultsTwo hundred nineteen randomized patients of whom 45% received BB were analyzed. There were no significant demographic or clinical differences between BB

conclusionPropranolol decreases in-hospital mortality and improves long-term functional outcome in isolated severe TBI. This randomized trial speaks in favor of routine administration of beta-blocker therapy as part of a standardized neurointensive care protocol. LEVEL OF EVIDENCE: Level II; therapeutic. STUDY TYPE: Therapeutic study.

Indexed as

Adrenergic beta-AntagonistsAdultBrain Injuries, TraumaticFemaleGlasgow Outcome ScaleHospital MortalityHumansMaleMiddle AgedPropranololProspective StudiesYoung AdultAdrenergic beta-AntagonistsPropranolol

Identifiers

PMID32002583
OpenAlexW3003760543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.