Evidence map›Paper›PMID 32002573›Full record

ArticleDiabetologia2020

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study.

Robert W Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N Giordano, Tom White, Jerzy Adamski, Jimmy D Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi and 25 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 18 institutions in 10 countries.

Robert W KoivulaDepartment of Clinical Sciences, Lund University, Genetic and Molecular Epidemiology, CRC, Skåne University Hospital Malmö, Building 91, Level 12, Jan Waldenströms gata 35, SE-205 02, Malmö, Sweden. robert.koivula@med.lu.se.ORCID http://orcid.org/0000-0002-1646-4163
Naeimeh Atabaki-PasdarDepartment of Clinical Sciences, Lund University, Genetic and Molecular Epidemiology, CRC, Skåne University Hospital Malmö, Building 91, Level 12, Jan Waldenströms gata 35, SE-205 02, Malmö, Sweden.
Giuseppe N GiordanoDepartment of Clinical Sciences, Lund University, Genetic and Molecular Epidemiology, CRC, Skåne University Hospital Malmö, Building 91, Level 12, Jan Waldenströms gata 35, SE-205 02, Malmö, Sweden.
Tom WhiteMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Jerzy AdamskiResearch Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Jimmy D BellResearch Centre for Optimal Health, Department of Life Sciences, University of Westminister, London, UK.
Joline BeulensDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam University Medical Centre, location VU University Medical Center, Amsterdam, the Netherlands.
Søren BrageMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Søren BrunakThe Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Federico De MasiThe Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Emmanouil T DermitzakisDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
Ian M ForgiePopulation Health & Genomics, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, UK.
Gary FrostNutrition and Dietetics Research Group, Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Hammersmith Campus, London, UK.
Torben HansenFaculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Tue H HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
Andrew HattersleyNIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK.
Tarja KokkolaDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Azra KurbasicDepartment of Clinical Sciences, Lund University, Genetic and Molecular Epidemiology, CRC, Skåne University Hospital Malmö, Building 91, Level 12, Jan Waldenströms gata 35, SE-205 02, Malmö, Sweden.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Andrea MariInstitute of Neurosciences, National Research Council, Padova, Italy.
Timothy J McDonaldNIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
Femke RuttersDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam University Medical Centre, location VU University Medical Center, Amsterdam, the Netherlands.
Jochen M SchwenkAffinity Proteomics, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.
Harriet J A TeareHeLEX, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Headington, Oxford, UK.
E Louise ThomasResearch Centre for Optimal Health, Department of Life Sciences, University of Westminister, London, UK.
Ana VinuelaDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
Anubha MahajanWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Mark I McCarthyOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Hartmut RuettenSanofi-Aventis Deutschland GmbH, R&D, Frankfurt am Main, Germany.
Mark WalkerInstitute of Cellular Medicine (Diabetes), Newcastle University, Newcastle upon Tyne, UK.
Ewan PearsonPopulation Health & Genomics, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, UK.
Imre PavoEli Lilly Regional Operations GmbH, Vienna, Austria.
Paul W FranksDepartment of Clinical Sciences, Lund University, Genetic and Molecular Epidemiology, CRC, Skåne University Hospital Malmö, Building 91, Level 12, Jan Waldenströms gata 35, SE-205 02, Malmö, Sweden.
IMI DIRECT Consortium
University of Copenhagen · DKLund University · SEAmsterdam UMC Location Vrije Universiteit Amsterdam · NLCentre for Human Genetics · GBUniversity of Dundee · GBUniversity of Eastern Finland · FIUniversity of Exeter · GBUniversity of Geneva · CHHammersmith Hospital · GBHarvard University · USNational Research Council · ITNational University of Singapore · SGNewcastle University · GBSanofi (Germany) · DEScience for Life Laboratory · SEUniversity of Cambridge · GBUniversity of Oxford · GBUniversity of Southern Denmark · DK

Funding

European Commission CoG-2015_681742_NASCENT [P.W.F.]Innovative Medicines Initiative 115317 (DIRECT)Medical Research Council MC_UU_00006/4Medical Research Council MC_UU_12015/3Medical Research Council MC_UU_12015/3 [S.Bra.]MedImmune PhD Fellowship [T.W.]Novo Nordisk STAR Novo Nordisk co-financed PhD fellowship [R.W.Novo Nordisk Fonden NNF18OC0031650 (Postdoctoral Fellowship)[R.W.K.]
6 · The paper itself

Abstract

aims/hypothesisIt is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypothesis (TC) provides a mechanistic basis for impairment in glycaemic control through the interactions of substrate availability, substrate metabolism and abdominal ectopic fat accumulation. Here, we hypothesise that the effect of physical activity in glucose regulation is mediated by the twin-cycle. We aimed to examine this notion in the Innovative Medicines Initiative Diabetes Research on Patient Stratification (IMI DIRECT) Consortium cohorts comprised of participants with normal or impaired glucose regulation (cohort 1: N ≤ 920) or with recently diagnosed type 2 diabetes (cohort 2: N ≤ 435).

methodsWe defined a structural equation model that describes the TC and fitted this within the IMI DIRECT dataset. A second model, twin-cycle plus physical activity (TC-PA), to assess the extent to which the effects of physical activity in glycaemic regulation are mediated by components in the twin-cycle, was also fitted. Beta cell function, insulin sensitivity and glycaemic control were modelled from frequently sampled 75 g OGTTs (fsOGTTs) and mixed-meal tolerance tests (MMTTs) in participants without and with diabetes, respectively. Abdominal fat distribution was assessed using MRI, and physical activity through wrist-worn triaxial accelerometry. Results are presented as standardised beta coefficients, SE and p values, respectively.

resultsThe TC and TC-PA models showed better fit than null models (TC: χ CONCLUSIONS/

interpretationThese analyses partially support the mechanisms proposed in the twin-cycle model and highlight mechanistic pathways through which insulin sensitivity and liver fat mediate the association between physical activity and glycaemic control.

Indexed as

AgedBlood GlucoseCohort StudiesCross-Sectional StudiesDenmarkDiabetes Mellitus, Type 2Energy MetabolismExerciseFemaleFinlandGlucose Tolerance TestGlycemic ControlHomeostasisHumansInsulin ResistanceMaleBlood GlucoseBeta cell functionEctopic fatGlycaemic controlInsulin sensitivityPhysical activityPrediabetesStructural equation modellingType 2 diabetes

Identifiers

PMID32002573
PMCPMC7054368
OpenAlexW3004161228

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.