Evidence map›Paper›PMID 32002194›Full record

ArticleJournal of drug assessment2020

Efficacy of lofexidine for mitigating opioid withdrawal symptoms: results from two randomized, placebo-controlled trials.

Danesh Alam, Carlos Tirado, Mark Pirner, Thomas Clinch

Open access · hybridAbstract read
In one paragraph

Article in Journal of drug assessment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
29.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 170 citations in OpenAlex.

  1. Pooled it
  2. Spontaneous daily sleep disruptions associated with morphine dependence and withdrawal in rats.The Journal of pharmacology and experimental therapeutics · 2025
    Article
  3. Article
  4. Noninvasive Vagal Nerve Stimulation for Opioid Use Disorder.Annals of depression and anxiety · 2023
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Danesh AlamNorthwestern Medicine Central DuPage Hospital, Winfield, IL, USA.
Carlos TiradoCARMA Health, PLLC, Austin, TX, USA.
Mark PirnerUS WorldMeds, LLC, Louisville, KY, USA.
Thomas ClinchUS WorldMeds, LLC, Louisville, KY, USA.
Peptides International (United States) · USNorthwestern Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

addictionalpha2-adrenergic agonistdetoxificationlofexidineopioid dependenceopioid use disorderOpioid withdrawalopioid withdrawal syndrome

Identifiers

PMID32002194
PMCPMC6968526
OpenAlexW3000311061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.