ArticleJournal of clinical orthopaedics and trauma
Severe metallosis-related osteolysis as a cause of failure after total knee replacement.
Article in Journal of clinical orthopaedics and trauma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Additively Manufactured Partially Porous PAEK Topologies for Proximal Tibia Revision Cones and Sleeves.Annals of biomedical engineering · 2026Article
- Review
- Progressive Loosening in Metal-on-Metal Total Hip Arthroplasty after Fifteen Years of Effective Function: Two Case Reports.Journal of orthopaedic case reports · 2025Article
- Third Body Wear of an All-Polymer, PEEK-OPTIMA™ on Ultra-High-Molecular-Weight Polyethylene Total Knee Replacement.Bioengineering (Basel, Switzerland) · 2025Article
- Influence of the Metallic Sublayer on Corrosion Resistance in Hanks' Solution of 316L Stainless Steel Coated with Diamond-like Carbon.Materials (Basel, Switzerland) · 2024Article
- Reactive Peri-Arthroplasty Pseudotumors: A Rare Cause of Hip Pain and Iatrogenic Sciatica.Cureus · 2023Article
- Serum cobalt and chromium concentration following total hip arthroplasty: a Bayesian network meta-analysis.Scientific reports · 2023Article
- Metallosis After Oxinium Total Knee Arthroplasty in a Patient With Rheumatoid Arthritis: A Case Report.Cureus · 2023Article
- Poly (Ether-Ether-Ketone) for Biomedical Applications: From Enhancing Bioactivity to Reinforced-Bioactive Composites-An Overview.Polymers · 2023Review
- Two-stage revision knee arthroplasty for metallosis in a patient with rheumatoid arthritis: A case report.SAGE open medical case reports · 2023Article
- Neurological emergency from rare spinal metalloma: Case report and literature review.Radiology case reports · 2022Article
- A novel revision system for complex pelvic defects utilizing 3D-printed custom prosthesis.Journal of orthopaedic translation · 2021Article
- An Interesting Case of Osteolysis With Accompanying Metallosis in a Primary Total Knee Arthroplasty.Arthroplasty today · 2021Article
- The Mechanism of Metallosis After Total Hip Arthroplasty.Regenerative engineering and translational medicine · 2021Article
- Revision of total knee replacement (TKR) secondary to raised cobalt levels: should this be considered in the painful TKR patient?BMJ case reports · 2021Article
- The Influence of Hybrid Surface Modification on the Selected Properties of CP Titanium Grade II Manufactured by Selective Laser Melting.Materials (Basel, Switzerland) · 2020Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetallosis is a syndrome of metal-induced synovitis caused by friction between two metal surfaces. In contrast to the hip joint after resurfacing arthroplasty or metal-on-metal (MoM) total hip replacement, metallosis of the knee is extremely rare. MATERIALS: We describe 4 patients who underwent revision total knee replacement because of disabling pain and implant loosening after a mean time of 21 (range: 13-30) years of knee replacement surgery. They were all females with a mean age of 79 (range: 75-82) years. Septic loosening was excluded through microbiological examination and synovial fluid analysis.
resultsDirect metal-on-metal contact at the tibiofemoral interface was confirmed intraoperatively in all cases. All knees showed severe metallosis with advanced osteolysis and pseudotumor formation. In one knee there was a complete fracture of the tibial tray. All patients had a one-stage revision surgery with implant removal, profound synovectomy and implantation of a constrained modular revision knee system. Long modular stems with offset adapters, wedges and/or blocks were used in all cases.
conclusionMetallosis-associated osteolysis should be suspected in cases with radiologically evident polyethylene wear after knee replacement. Recognizing that revision arthroplasty is very technically demanding in such cases, surgeons should have a back-up with modular revision components and a ready access to reconstructive options at this revision setting.
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