ArticleJournal of clinical orthopaedics and trauma
A comparative study of 5 different antibiotic prophylaxis regimes in 4500 total knee replacements.
Article in Journal of clinical orthopaedics and trauma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Single-DoseIndian journal of orthopaedics · 2025Article
- Observational
- The Impact of Patient-Reported Penicillin or Cephalosporin Allergy on the Occurrence of the Periprosthetic Joint Infection in Primary Knee and Hip Arthroplasty.Antibiotics (Basel, Switzerland) · 2022Article
- Arthroscopic rotator cuff repair without antibiotic prophylaxis does not increase the infection rate.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- Intraoperative Bacterial Contamination and Activity of Different Antimicrobial Prophylaxis Regimens in Primary Knee and Hip Replacement.Antibiotics (Basel, Switzerland) · 2020Article
- Antibiotic prophylaxis in orthopedic surgery; has the time to reconsider the current practice arrived?Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare the incidence of surgical site infection with different antibiotic regimes in elective total knee arthroplasty. We hypothesise that a single high dose of Teicoplanin and Gentamicin is as effective as other regimes.
methodsA retrospective study of prospectively collected data on a total of 4500 elective knee replacements over a 9-year period was conducted in a district general hospital. Data were collected on antibiotic regime, patient characteristics, infection (treatment, infective agents, sensitivities) and complications.
resultsFive different antibiotic regimes that have been used in elective knee arthroplasty were identified in our institution. 40 patients in total were identified who had a deep infection. Rates of deep surgical site infection were not significantly different between the five groups (p = 0.83).
conclusionA single pre-operative dose of Teicoplanin and Gentamicin has similar efficacy of prophylaxis to other regimes for patients undergoing primary elective total knee replacements. We recommend the choice of prophylaxis regimen is made locally based on pathogen virulence, drug resistance and cost.
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