ArticleJournal of clinical biochemistry and nutrition2020
Salivary 8-hydroxyguanine as a lifestyle-related oxidative stress biomarker in workers.
Article in Journal of clinical biochemistry and nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Assessment of exposure and DNA damage from second-hand smoke using potential biomarker in urine: cigarettes and heated tobacco products.Journal of clinical biochemistry and nutrition · 2023Article
- The Role of Potential Oxidative Biomarkers in the Prognosis of Acute Ischemic Stroke and the Exploration of Antioxidants as Possible Preventive and Treatment Options.International journal of molecular sciences · 2023Review
- 8-oxoguanine and 8-oxodeoxyguanosine Biomarkers of Oxidative DNA Damage: A Review on HPLC-ECD Determination.Molecules (Basel, Switzerland) · 2022Review
- Urinary biomarkers for secondhand smoke and heated tobacco products exposure.Journal of clinical biochemistry and nutrition · 2021Article
- Health examination results and work environment factors affecting urinary 8-hydroxy-2'-deoxyguanosine levels.Journal of occupational health · 2021Article
- Effects of smoking cessation on biological monitoring markers in urine.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020Article
- Diurnal variation of salivary oxidative stress marker 8-hydroxyguanine.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2019Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is a risk factor for lifestyle-related diseases, such as cancer. Investigations of the factors that increase or decrease oxidative stress contribute to disease prevention. In the present study, we focused on the 8-hydroxyguanine (8-OHGua) in saliva, as a new oxidative stress biomarker. The relationship between lifestyles and salivary 8-OHGua levels in 541 Japanese subjects was analyzed. The salivary 8-OHGua levels were significantly elevated in older persons, as well as those who smoke, have hypertension, or excess visceral fat. By contrast, statistically significant lower levels of 8-OHGua were observed in persons who moderately exercised or recently drank green tea or coffee. The direct collection of saliva, without any special collecting device, was suitable for the 8-OHGua analysis. The present results suggest that oxidative stress can be measured in a non-invasive manner with easily collectable saliva, and the salivary 8-OHGua may be a useful biomarker for lifestyle-related disease prevention.
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