ArticleIndian journal of psychiatry
Prediction of schizophrenia using MAOA-uVNTR polymorphism: A case-control study.
Article in Indian journal of psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Association of Monoamine Oxidase A Gene Promoter Region (30 bp μVNTR) Polymorphism with Serum Levels in Multiple Psychiatric Disorders.Biomedicines · 2025Article
- Dopaminergic Epistases in Schizophrenia.Brain sciences · 2024Review
- Article
- Serotonin transporter functional polymorphisms potentially increase risk of schizophrenia separately and as a haplotype.Scientific reports · 2022Article
- Altered states, alkaloids, and catatonia: Monoaminoxidase inhibitors and their role in the history of psychopharmacology.Frontiers in pharmacology · 2022Review
- Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia.Neuropsychiatric disease and treatment · 2021Article
- Genetic polymorphism and neuroanatomical changes in schizophrenia.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextSchizophrenia has been associated with disorder of the dopamine system, which is downregulated by projections of the serotonin pathway. Dopamine and serotonin levels are regulated by a system of transporters and enzymes. In this research, dopamine transporter polymorphism (DAT-VNTR), serotonin transporter polymorphism (5-HTTLPR), monoamine oxidase A (MAOA-uVNTR), and catechol-o-methyl transferase (COMT Val158Met) polymorphisms have been investigated.
aimsThe aim of this study was to asses frequencies of these polymorphisms in the healthy control group and patients and to asses association with schizophrenia. SETTINGS AND
designThree hundred and fourteen healthy volunteers and 306 schizophrenia patients were included. Schizophrenia was diagnosed by Diagnostic and Statistical Manual-IV of the American Psychiatric Association, and mini international neuropsychiatric interview questionnaire was used for screening of healthy population. MATERIALS AND
methodsGenotyping was performed using polymerase chain reaction (PCR) reaction followed by gel electrophoresis and PCR-restriction fragment length polymorphism. STATISTICAL ANALYSIS: Categorical data were analyzed using the Chi-square test, age between subgroups was compared using the Mann-Whitney test, and all polymorphisms were tested for Hardy-Weinberg equilibrium. Logistic regression analysis was used to set the prediction model of schizophrenia.
resultsDifference in genotype distribution was observed for COMT Val158Met in female and DAT-VNTR polymorphism in overall sample
conclusionOur results suggest an association of MAOA-uVNTR polymorphism with schizophrenia. The difference in the distribution of COMT Val158Met and DAT-VNTR polymorphism support the involvement of dopamine system components in the pathogenesis of schizophrenia.
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