ArticleSpinal cord2020
The incidence and etiology of sperm DNA fragmentation in the ejaculates of males with spinal cord injuries.
Article in Spinal cord, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Sexual Dysfunction and Infertility in Male Patients With Spinal Cord Injury: A Narrative Review.Cureus · 2026Review
- Hurdles of Sperm Success: Exploring the Role of DNases.International journal of molecular sciences · 2025Review
- Therapeutic effects of erythropoietin-alginate/chitosan hydrogel on impaired male rat fertility after spinal cord injury.Molecular biology reports · 2025Article
- Sperm DNA Fragmentation and Fertility.Advances in experimental medicine and biology · 2025Review
- Role of DNase Activity in Human Sperm DNA Fragmentation.Biomolecules · 2024Review
- Advanced Paternal Age Affects the Sperm DNA Fragmentation Index and May Lead to Lower Good-quality Blastocysts.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Sperm DNA Damage and Its Relevance in Fertility Treatment: A Review of Recent Literature and Current Practice Guidelines.International journal of molecular sciences · 2023Review
- Relevance of Leukocytospermia and Semen Culture and Its True Place in Diagnosing and Treating Male Infertility.The world journal of men's health · 2022Review
- Free circulating DNA and DNase activity in the ejaculates of men with spinal cord injury.Spinal cord · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designRetrospective descriptive study.
objectivesTo determine the incidence and probable etiology of sperm DNA fragmentation (SDF) in a sample of males with spinal cord injury (SCI).
settingHospital in Toledo, Spain; University-based Genetics laboratory in Madrid, Spain.
methodsSemen collected by vibro-stimulation from 27 males with various levels of spinal cord injury. Classical semen parameters, SDF, leukocytospermia and pro-oxidant capacity were assessed and compared with a cohort of normozoospermic fertile donors (n = 10).
resultsMales with SCI presented with lower semen quality compared with normozoospermic donors with respect to progressive motility (p = 0.0002), SDF (p < 0.00005), pro-oxidant capacity (p = 0.0191) and leukocytospermia (p < 0.00005). Although there was no significant correlation between semen quality and time since the lesion occurred, the period of abstinence appeared to be positively correlated with SDF (r = 0.486; p = 0.041). When the semen parameters of males with SCI were categorized based on those with cervical and thoracic lesions, sperm concentration was higher for those with cervical damage (p = 0.0257). Males with complete lesions (AIS A) had ejaculates that were lower in progressive motility (p = 0.0040) than those with incomplete injuries (AIS B-D).
conclusionsEjaculates of males with SCI have excessively elevated SDF when compared with normozoospermic donors, which is likely to be associated with coincident high levels of leucocytospermia and pro-oxidant capacity. We propose that these phenomena are caused by the accumulation and degeneration of spermatozoa in the cauda epididymidis.
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