Evidence map›Paper›PMID 32001774›Full record

ArticleScientific reports2020

Co-existence of PrP

Ignazio Cali, Gianfranco Puoti, Jason Smucny, Paul Michael Curtiss, Laura Cracco, Tetsuyuki Kitamoto, Rossana Occhipinti, Mark Lloyd Cohen, Brian Stephen Appleby, Pierluigi Gambetti

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  5. Review
  6. Article
  7. Review
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  11. Article
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  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Two distinct conformers of PrPActa neuropathologica communications · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ignazio CaliDepartment of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Gianfranco PuotiDepartment of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Caserta, 81100, Italy.
Jason SmucnyDepartment of Psychiatry, University of California, Davis, CA, 95616, USA.
Paul Michael CurtissNew York University, School of Medicine, New York, NY, 10016, USA.
Laura CraccoDepartment of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Tetsuyuki KitamotoDepartment of Neurological Science, Tohoku University Graduate School of Medicine, Sendai, 980-8576, Japan.
Rossana OcchipintiDepartment of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Mark Lloyd CohenDepartment of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Brian Stephen ApplebyDepartment of Neurology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Pierluigi GambettiDepartment of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA. pxg13@case.edu.

Funding

Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Jason C Bartz · 2008 to 2026
$36.1M
Translational and Therapeutics CoreP30AG072959 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI JAGAN AYYAPPAN PILLAI · 2021 to 2026
$23.9M
Neuropathology Core - P GambettiP01AI106705 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI GAMBETTI, PIERLUIGI · 2014 to 2018
$7.7M
Translational Therapeutics CoreP30AG062428 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI LERNER, ALAN J · 2019 to 2020
$5.0M
Structural correlates of prion strain, phenotype and infectivity in human prion dR01NS083687 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI GAMBETTI, PIERLUIGI, SUREWICZ, WITOLD K · 2014 to 2018
$2.9M
Acid secretion and intracellular pH regulation in proximal-tubule cellsK01DK107787 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI OCCHIPINTI, ROSSANA · 2015 to 2019
$541k
NIAID NIH HHS P01 AI077774NIAID NIH HHS P01 AI106705NIA NIH HHS P30 AG062428NIA NIH HHS P30 AG072959NIDDK NIH HHS K01 DK107787NINDS NIH HHS R01 NS083687
6 · The paper itself

Abstract

We report a detailed study of a cohort of sporadic Creutzfeldt-Jakob disease (sCJD) VV1-2 type-mixed cases (valine homozygosity at codon 129 of the prion protein, PrP, gene harboring disease-related PrP, PrP

Indexed as

AdultAgedAged, 80 and overBrainCohort StudiesCreutzfeldt-Jakob SyndromeFemaleGenetic Association StudiesHumansMaleMiddle AgedProtein ConformationProtein StabilityPrPSc ProteinsTissue DistributionValinePrPSc ProteinsValine

Identifiers

PMID32001774
PMCPMC6992672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.