ArticleScientific reports2020
Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies.Addiction biology · 2024Pooled it
- Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.Molecular psychiatry · 2023Pooled it
- Early Adulthood Signatures of Motherhood in Brain Aging.Human brain mapping · 2026Article
- Brain aging patterns among nine neurological disorders: A case-control study.PLoS medicine · 2026Article
- Metabolomic ageing across mental and behavioural disorders.BMJ mental health · 2026Article
- Surface-based brain age index reflects hematological impacts on cognitive development in children with beta-thalassemia major.iScience · 2026Article
- Exposome-wide patterns predict brain health in aging.Nature communications · 2026Article
- Article
- Nicotine-Mediated Alterations in Exosome Content: Implications for Stroke and Neurological Dysfunction.Biomolecules · 2026Review
- Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration.medRxiv : the preprint server for health sciences · 2026Article
- Biological brain aging, cognitive-motor decline and vascular risk: a multivariate imaging analysis of 40,579 individuals.Frontiers in aging neuroscience · 2026Article
- Neuroanatomical features reveal accelerated brain age in alcohol use disorder.bioRxiv : the preprint server for biology · 2025Article
- Integration of Genetic Information to Improve Brain Age Gap Estimation Models in the UK Biobank.Human brain mapping · 2025Article
- Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health.Nature aging · 2025Article
- Fitness and exercise effects on brain age: A randomized clinical trial.Journal of sport and health science · 2025Article
- Associations between epigenetic age and brain age in young people.Scientific reports · 2025Article
- Atrophy related neuroimaging biomarkers for neurological and cognitive function in Wilson disease.Neurological research and practice · 2025Article
- Genetically supported targets and drug repurposing for brain aging: A systematic study in the UK Biobank.Science advances · 2025Article
- Greater alcohol intake predicts accelerated brain aging in humans, which mediates the relationship between alcohol intake and behavioral inflexibility.Alcohol, clinical & experimental research · 2025Article
- Participation in Healthy Ageing Centres in Bosnia and Herzegovina Is Associated with Increased Physical Activity, Social Interactions, and Life Satisfaction Among Older People: A Cross-Sectional Study.Journal of ageing and longevity · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Brain age is a metric that quantifies the degree of aging of a brain based on whole-brain anatomical characteristics. While associations between individual human brain regions and environmental or genetic factors have been investigated, how brain age is associated with those factors remains unclear. We investigated these associations using UK Biobank data. We first trained a statistical model for obtaining relative brain age (RBA), a metric describing a subject's brain age relative to peers, based on whole-brain anatomical measurements, from training set subjects (n = 5,193). We then applied this model to evaluation set subjects (n = 12,115) and tested the association of RBA with tobacco smoking, alcohol consumption, and genetic variants. We found that daily or almost daily consumption of tobacco and alcohol were both significantly associated with increased RBA (P < 0.001). We also found SNPs significantly associated with RBA (p-value < 5E-8). The SNP most significantly associated with RBA is located in MAPT gene. Our results suggest that both environmental and genetic factors are associated with structural brain aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.