ArticleNature communications2020
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.
Registry-linked trialAbstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 398 papers, 12 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
398citing papers in PubMed, 12 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
Who cites it
398 citing papers in PubMed, 12 syntheses or guidelines pooled it.
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- Immunocytes Mediate the Effects of Gut Microbiome on Inflammatory Bowel Disease: Insights From a Mendelian Randomization Study.Mediators of inflammation · 2025Pooled it
- Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer.International journal of medical sciences · 2025Pooled it
- Immune cells mediate the causal pathway linking circulating complements to cancer: A Mendelian randomization study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Pooled it
- Association between human herpesviruses infections and childhood neurodevelopmental disorders: insights from two-sample mendelian randomization analyses and systematic review with meta-analysis.Italian journal of pediatrics · 2024Pooled it
- Coffee and Risk of Pancreatic Cancer: Insights from Two-Sample and Multivariable Mendelian Randomization Analyses.Nutrients · 2024Pooled it
- Investigating causal links between gallstones, cholecystectomy, and 33 site-specific cancers: a Mendelian randomization post-meta-analysis study.BMC cancer · 2024Pooled it
- Association of lipid-lowering drugs with risk of sarcopenia: a drug target mendelian randomization study and meta-analysis.Human genomics · 2024Pooled it
- Frailty and abdominal wall hernias: a Mendelian randomization and retrospective study.Surgical endoscopy · 2026Article
- Exercise therapy in cancer prevention and treatment.Nature reviews. Clinical oncology · 2026Review
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- Cerebrospinal Fluid Metabolites Mediate Immune Cell Effects on Chronic Pain.Molecular neurobiology · 2026Article
- Association Between Socioeconomic Status and Atrial Fibrillation: A Two-Sample Mendelian Randomization Study.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- The causal effect of family history of cardiovascular disease on erectile dysfunction: a randomized clinical study and Mendelian randomization study.Asian journal of andrology · 2026Article
- Association Between Oral Cavity Cancer and Lymphoma: A Bidirectional Mendelian Randomization Analysis.Oral health & preventive dentistry · 2026Article
- Trends and burden of colon and rectum cancer attributable to low physical activity in China: a comprehensive analysis from 1990 to 2021.Cancer causes & control : CCC · 2026Article
338 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
82 authors.
Nikos PapadimitriouSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Niki DimouSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Konstantinos K TsilidisDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.ORCID http://orcid.org/0000-0002-8452-8472
Barbara BanburyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Richard M MartinMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7992-7719
Sarah J LewisBristol Medical School, Department of Population Health Sciences, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-4311-6890
Nabila KazmiMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Timothy M RobinsonBristol Medical School, Department of Population Health Sciences, University of Bristol, Bristol, UK.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MA, USA.
Krasimira AleksandrovaGerman Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MA, USA.
D Timothy BishopLeeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-8752-8785
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Daniel D BuchananCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-2225-6675
Bas Bueno-de-MesquitaFormer senior scientist, Dept. for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA, Bilthoven, Netherlands.
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
Sergi Castellví-BelGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7284-6767
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Merete Ellingjord-DaleDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Jane C FigueiredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Steven J GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-4946-9099
Edward GiovannucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Stephen B GruberDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Andrea GsurInstitute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-9795-1528
Jochen HampeDepartment of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.ORCID http://orcid.org/0000-0002-2421-6127
Heather HampelDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-7558-9794
Sophia HarlidDepartment of Radiation Sciences, Oncology, Umea University, 901 87, Umea, Sweden.ORCID http://orcid.org/0000-0001-8540-6891
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4173-7530
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
José María HuertaCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.ORCID http://orcid.org/0000-0002-9637-3869
Jeroen R HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6027-9806
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-8964-6160
Temitope O KekuCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Carlo La VecchiaHellenic Health Foundation, Athens, Greece.ORCID http://orcid.org/0000-0003-1441-897X
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Christopher I LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.
Annika LindblomDepartment of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Noralane M LindorDepartment of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA.
Brigid LynchCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Sanford D MarkowitzDepartments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, OH, USA.
Giovanna MasalaCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy.ORCID http://orcid.org/0000-0002-5758-9069
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, 3508 GA, UTRECHT, Netherlands.
Roger MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-5764-7268
Evelyn MonninkhofJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, 3508 GA, UTRECHT, Netherlands.
Lorena MorenoGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
Victor MorenoCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.ORCID http://orcid.org/0000-0002-2818-5487
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8786-0043
Kenneth OffitClinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Vittorio PerducaCESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-Saclay, 94805, Villejuif, France.ORCID http://orcid.org/0000-0003-0339-0473
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8494-732X
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5439-1500
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.ORCID http://orcid.org/0000-0002-8512-068X
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Maria-Jose SánchezCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Stephanie L SchmitDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5931-1194
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7153-2766
Gianluca SeveriCESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-Saclay, 94805, Villejuif, France.
Sabina SieriEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Martha L SlatteryDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Mingyang SongDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Catherine M TangenSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Stephen N ThibodeauDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF, Oxford, UK.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Cornelia M UlrichHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.
Franzel J B van DuijnhovenDivision of Human Nutrition, Wageningen University and Research, Wageningen, Netherlands.
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-9692-101X
Pavel VodickaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7387-6845
Michael O WoodsMemorial University of Newfoundland, Discipline of Genetics, St. John's, Canada.
Anna H WuUniversity of Southern California, Preventative Medicine, Los Angeles, CA, USA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5666-9318
Marc J Gunter *Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Neil Murphy *Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France. MurphyN@iarc.fr.ORCID http://orcid.org/0000-0003-3347-8249
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MPLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9MTargeting 15-PGDH in Colon Cancer Prognosis, Prediction, Treatment and PreventionP50CA150964 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2011 to 2022
$24.6MTransdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6MData sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8MUsing Functional Genomics to Inform Gene Environment Interactions for Colorectal CancerR01CA201407 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GAUDERMAN, WILLIAM JAMES, LE MARCHAND, LOIC · 2016 to 2020
$9.6MFHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600kCancer Research UK 19169Cancer Research UK 29019Cancer Research UK C18281/A19169NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA150964NCI NIH HHS R01 CA201407NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA206110NIEHS NIH HHS P30 ES010126NIH HHS S10 OD020069World Health Organization 001
Abstract
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER
Indexed as
ExerciseGenetic Predisposition to DiseaseMendelian Randomization AnalysisAccelerometryBreast NeoplasmsColorectal NeoplasmsFemaleHumansOdds RatioPolymorphism, Single NucleotideRisk Factors
Identifiers
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Registered trials
NCT02328677ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.