Evidence map›Paper›PMID 32001655›Full record

ArticleScience (New York, N.Y.)2020

Engineered symbionts activate honey bee immunity and limit pathogens.

Sean P Leonard, J Elijah Powell, Jiri Perutka, Peng Geng, Luke C Heckmann, Richard D Horak, Bryan W Davies, Andrew D Ellington, Jeffrey E Barrick, Nancy A Moran

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
32.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 262 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. The symbiotic bacteriaMicrobiology spectrum · 2026
    Article
  6. Review
  7. Article
  8. Article
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  11. Article
  12. Review
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  19. Article
  20. An ancient immune pathway enables animal metamorphosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sean P LeonardDepartment of Integrative Biology, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-5634-3254
J Elijah PowellDepartment of Integrative Biology, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-2758-6174
Jiri PerutkaDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-4661-2382
Peng GengDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Luke C HeckmannDepartment of Integrative Biology, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-8742-7634
Richard D HorakDepartment of Integrative Biology, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0003-0630-5481
Bryan W DaviesDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-2046-0341
Andrew D EllingtonDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-6246-5338
Jeffrey E BarrickDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA. nancy.moran@austin.utexas.edu jbarrick@cm.utexas.edu.ORCID 0000-0003-0888-7358
Nancy A MoranDepartment of Integrative Biology, The University of Texas at Austin, Austin, TX 78712, USA. nancy.moran@austin.utexas.edu jbarrick@cm.utexas.edu.ORCID 0000-0003-2983-9769
The University of Texas at Austin · US

Funding

Host and symbiont determinants of colonization by a co-evolved gut communityR01GM108477 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MORAN, NANCY A. · 2014 to 2018
$1.4M
NIGMS NIH HHS R01 GM108477
6 · The paper itself

Abstract

Honey bees are essential pollinators threatened by colony losses linked to the spread of parasites and pathogens. Here, we report a new approach for manipulating bee gene expression and protecting bee health. We engineered a symbiotic bee gut bacterium,

Indexed as

AnimalsBeesGastrointestinal MicrobiomeGenetic EngineeringNeisseriaceaeRNA InterferenceSymbiosisVarroidae

Identifiers

PMID32001655
PMCPMC7556694
OpenAlexW3003740439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.