Evidence map›Paper›PMID 32001618›Full record

ArticleThe Journal of biological chemistry2020

The DNA repair enzyme MUTYH potentiates cytotoxicity of the alkylating agent MNNG by interacting with abasic sites.

Alan G Raetz, Douglas M Banda, Xiaoyan Ma, Gege Xu, Anisha N Rajavel, Paige L McKibbin, Carlito B Lebrilla, Sheila S David

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Biochemical analysis of HDNA repair · 2024
    Article
  5. Pan-Cancer Interrogation ofJCO precision oncology · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alan G RaetzDepartment of Chemistry, University of California, Davis, California 95616.
Douglas M BandaDepartment of Chemistry, University of California, Davis, California 95616.
Xiaoyan MaDepartment of Chemistry, University of California, Davis, California 95616.
Gege XuDepartment of Chemistry, University of California, Davis, California 95616.
Anisha N RajavelDepartment of Chemistry, University of California, Davis, California 95616.
Paige L McKibbinDepartment of Chemistry, University of California, Davis, California 95616.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, California 95616.
Sheila S DavidDepartment of Chemistry, University of California, Davis, California 95616. Electronic address: ssdavid@ucdavis.edu.
University of California, Davis · USUniversity of California System · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
The incorporation of human milk oligosaccharides in brain glycoconjugatesR01GM049077 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEBRILLA, CARLITO B · 1999 to 2024
$6.3M
RECOGNITION AND REPAIR OF MISMATCHED DNA BY MUTYR01CA067985 · NCI · UNIVERSITY OF UTAH · PI DAVID, SHEILA SUE · 2000 to 2025
$5.6M
NCI NIH HHS R01 CA067985NIGMS NIH HHS R01 GM049077
6 · The paper itself

Abstract

Higher expression of the human DNA repair enzyme MUTYH has previously been shown to be strongly associated with reduced survival in a panel of 24 human lymphoblastoid cell lines exposed to the alkylating agent

Indexed as

DNA RepairAlkylating AgentsAnimalsBase SequenceCell DeathCell SurvivalCross-Linking ReagentsDNADNA-(Apurinic or Apyrimidinic Site) LyaseDNA DamageDNA GlycosylasesFibroblastsGuanineHumansKineticsMethylnitronitrosoguanidineAlkylating AgentsApex1 protein, mouseCross-Linking ReagentsDNADNA-(Apurinic or Apyrimidinic Site) LyaseDNA GlycosylasesGuanineMethylnitronitrosoguanidineMutant ProteinsmutY adenine glycosylaseO-(6)-methylguanineRecombinant ProteinsSchiff Basesabasic sitesbase excision repair (BER)cancer biologycancer chemopreventionDNA damageDNA damage responseDNA enzymeDNA methylationDNA repairmutY homolog (MUTYH)

Identifiers

PMID32001618
PMCPMC7076218
OpenAlexW3003573515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.