Evidence map›Paper›PMID 32001446›Full record

Observational studyAJNR. American journal of neuroradiology2020

DWI-Based Algorithm to Predict Disability in Patients Treated with Thrombectomy for Acute Stroke.

H Raoult, M V Lassalle, B Parat, C Rousseau, F Eugène, S Vannier, S Evain, A Le Bras, T Ronziere, J C Ferre and 2 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

H RaoultFrom the Departments of Neuroradiology (H.R., B.P., F.E., J.C.F., J.Y.G.) helene.raoult@chu-rennes.fr.ORCID 0000-0002-0458-3309
M V LassalleNeurology (M.V.L., S.V., T.R.).ORCID 0000-0001-6958-2545
B ParatFrom the Departments of Neuroradiology (H.R., B.P., F.E., J.C.F., J.Y.G.).ORCID 0000-0002-8658-4603
C RousseauClinical Pharmacology (C.R., B.L.), Institut National de la Santé et de la Recherche Médicale, Centre d'Investigation Clinique de Rennes, Centre Hospitalier Universitaire Rennes, Rennes, France.ORCID 0000-0003-2466-4445
F EugèneFrom the Departments of Neuroradiology (H.R., B.P., F.E., J.C.F., J.Y.G.).ORCID 0000-0001-7367-8793
S VannierNeurology (M.V.L., S.V., T.R.).ORCID 0000-0002-4344-9102
S EvainDepartments of Neurology (S.E.).ORCID 0000-0003-4099-9552
A Le BrasRadiology (A.L.B.), Centre Hospitalier Universitaire Bretagne Atlantique, Vannes, France.ORCID 0000-0001-5691-3894
T RonziereNeurology (M.V.L., S.V., T.R.).ORCID 0000-0001-7632-7817
J C FerreFrom the Departments of Neuroradiology (H.R., B.P., F.E., J.C.F., J.Y.G.).ORCID 0000-0003-3911-1800
J Y GauvritFrom the Departments of Neuroradiology (H.R., B.P., F.E., J.C.F., J.Y.G.).ORCID 0000-0002-8057-6004
B LaviolleClinical Pharmacology (C.R., B.L.), Institut National de la Santé et de la Recherche Médicale, Centre d'Investigation Clinique de Rennes, Centre Hospitalier Universitaire Rennes, Rennes, France.ORCID 0000-0002-9541-6708
Centre Hospitalier Universitaire de Rennes · FRCIC Rennes · FRCentre hospitalier Bretagne Atlantique · FRNeurology, Inc · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe reasons for poor clinical outcome after thrombectomy for acute stroke, concerning around half of all patients, are misunderstood. We developed a hierarchic algorithm based on DWI to better identify patients at high risk of disability. MATERIALS AND

methodsOur single-center, retrospective study included consecutive patients with acute ischemic stroke who underwent thrombectomy for large anterior artery occlusion and underwent pretreatment DWI. The primary outcome was the mRS at 3 months after stroke onset. Multivariable regression was used to identify independent clinical and imaging predictors of poor prognosis (mRS > 2) at 3 months, and a hierarchic algorithm predictive of disability was developed.

resultsA total of 149 patients were analyzed. In decreasing importance, DWI lesion volume of >80 mL, baseline NIHSS score of >14, age older than 75 years, and time from stroke onset to groin puncture of >4 hours were independent predictors of poor prognosis. The predictive hierarchic algorithm developed from the multivariate analysis predicted the risk of disability at 3 months for up to 100% of patients with a high predictive value. The area under the receiver operating characteristic curve was 0.87.

conclusionsThe DWI-based hierarchic algorithm we developed is highly predictive of disability at 3 months after thrombectomy and is easy to use in routine practice.

Indexed as

AlgorithmsTreatment OutcomeAgedAged, 80 and overDiffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsROC CurveStrokeThrombectomy

Identifiers

PMID32001446
PMCPMC7015200
OpenAlexW3003264904

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.