Evidence map›Paper›PMID 32001099›Full record

ReviewTrends in microbiology2020

Flexibility and Adaptability of Quorum Sensing in Nature.

Rebecca D Prescott, Alan W Decho

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Frontiers in microbiology · 2026
    Article
  4. Article
  5. Article
  6. The role of MorI/MorR quorum sensing inMicrobiology spectrum · 2025
    Article
  7. Anti-QS Strategies AgainstMicroorganisms · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Beyond Antibiotics: What the Future Holds.Antibiotics (Basel, Switzerland) · 2024
    Review
  15. Article
  16. Anti-Biofilm and Anti-Quorum-Sensing Activity ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Rebecca D PrescottSchool of Physics and Astronomy, University of Edinburgh, Edinburgh, EH9 3FD, UK; Microbial Interactions Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA. Electronic address: rebeccap@hawaii.edu.
Alan W DechoMicrobial Interactions Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
University of South Carolina · US

Funding

Shared Services Center NASA 80NSSC18K1064
6 · The paper itself

Abstract

Quorum sensing (QS), a type of chemical communication, allows bacteria to sense and coordinate activities in natural biofilm communities using N-acyl homoserine lactones (AHLs) as one type of signaling molecule. For AHL-based communication to occur, bacteria must produce and recognize the same signals, which activate similar genes in different species. Our current understanding of AHL-QS suggests that signaling between species would arise randomly, which is not probable. We propose that AHL-QS signaling is a mutable and adaptable process, within limits. AHLs are highly-conserved signals, however, their corresponding receptor proteins (LuxR) are highly variable. We suggest that both flexibility and adaptation occur among receptor proteins, allowing for complex signaling networks to develop in biofilms over time.

Indexed as

4-ButyrolactoneAcyl-ButyrolactonesAliivibrio fischeriAmbulancesBacteriaBacterial ProteinsBiofilmsQuorum SensingRepressor ProteinsTrans-ActivatorsTranscription Factors4-ButyrolactoneAcyl-ButyrolactonesBacterial ProteinsLuxI protein, BacteriaLuxR autoinducer binding proteinsRepressor ProteinsTrans-ActivatorsTranscription Factorsbiofilmshomoserine lactonesintercellular signalingLuxILuxRquorum sensing

Identifiers

PMID32001099
PMCPMC7526683
OpenAlexW3003456876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.