Evidence map›Paper›PMID 32000855›Full record

ArticleBMC research notes2020

An open-source video tracking system for mouse locomotor activity analysis.

Chen Zhang, Haiwen Li, Renzhi Han

Open access · goldAbstract read
In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chen ZhangDepartment of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Haiwen LiDepartment of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Renzhi HanDepartment of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA. renzhi.han@osumc.edu.ORCID http://orcid.org/0000-0002-8202-9186
The Ohio State University Wexner Medical Center · US

Funding

Molecular and cellular functions of Ano5 in heartR01HL116546 · NHLBI · OHIO STATE UNIVERSITY · PI HAN, RENZHI · 2013 to 2022
$4.4M
NHLBI NIH HHS R01 HL116546
6 · The paper itself

Abstract

objectiveThe ability to accurately and efficiently quantify mouse locomotor activity is essential for evaluating therapeutic efficacy and phenotyping genetically modified mice, in particular for the research of neuromuscular diseases. Our objective is to develop a program for video tracking of mice and locomotion analysis.

resultsHere we describe a MATLAB program for video tracking of mice and locomotion analysis. The system is composed of a webcam, an open field, and a computer with MATLAB installed. Animal behavior is recorded by the webcam and the video is then analyzed for mouse position on each frame by a customized MATLAB code. The system has been tested for analyzing two or more mice simultaneously placed in individual chambers. The accumulative moving distance, velocity and thigmotaxis (percentage of time spending in the outer peripheral of the arena, which is commonly used as an index of anxiety) within a test period can be readily obtained. This system can be easily implemented in any laboratory as an in vivo locomotion assay to assess the neuromuscular abnormality of genetically modified animals and the impact of therapeutic interventions.

Indexed as

Video RecordingAnimalsDisease Models, AnimalInflammatory Bowel DiseasesLocomotionMice, Inbred C57BLMice, Inbred mdxMuscular Dystrophy, DuchenneLocomotor activityMiceNeuromuscular diseasesVideo tracking

Identifiers

PMID32000855
PMCPMC6990588
OpenAlexW3008405175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.