Evidence map›Paper›PMID 32000778›Full record

ArticleMicrobial cell factories2020

The effects of external Mn

Balázs Fejes, Jean-Paul Ouedraogo, Erzsébet Fekete, Erzsébet Sándor, Michel Flipphi, Áron Soós, Ákos P Molnár, Béla Kovács, Christian P Kubicek, Adrian Tsang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Microbial cell factories, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  8. Bioreactor as the root cause of the "manganese effect" duringFrontiers in bioengineering and biotechnology · 2022
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Balázs FejesDepartment of Biochemical Engineering, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, 4032, Hungary.
Jean-Paul OuedraogoCentre for Structural and Functional Genomics, Concordia University, Montreal, QC, Canada.
Erzsébet FeketeDepartment of Biochemical Engineering, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, 4032, Hungary.
Erzsébet SándorInstitute of Food Science, Faculty of Agricultural and Food Science and Environmental Management, University of Debrecen, Böszörményi út 138, Debrecen, 4032, Hungary.
Michel FlipphiDepartment of Biochemical Engineering, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, 4032, Hungary.
Áron SoósInstitute of Food Science, Faculty of Agricultural and Food Science and Environmental Management, University of Debrecen, Böszörményi út 138, Debrecen, 4032, Hungary.
Ákos P MolnárDepartment of Biochemical Engineering, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, 4032, Hungary.
Béla KovácsInstitute of Food Science, Faculty of Agricultural and Food Science and Environmental Management, University of Debrecen, Böszörményi út 138, Debrecen, 4032, Hungary.
Christian P KubicekInstitute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.
Adrian TsangCentre for Structural and Functional Genomics, Concordia University, Montreal, QC, Canada.
Levente KaraffaDepartment of Biochemical Engineering, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, 4032, Hungary. levente.karaffa@science.unideb.hu.ORCID http://orcid.org/0000-0002-3077-8732
University of Debrecen · HUConcordia University · CATU Wien · AT

Funding

Bólyai János Research Scholarship BO/00093/18/8EU and co-financed by the European Regional Development Fund GINOP-2.3.2-15-2016-00008European Union and the European Social Fund EFOP-3.6.1-16-2016-00022Hungarian National Research, Development and Innovation Fund KH129602Hungarian National Research, Development and Innovation Fund NN128867New National Excellence Program Ministry for Innovation and Technology ÚNKP-19-3New National Excellence Program Ministry for Innovation and Technology ÚNKP-19-4
6 · The paper itself

Abstract

backgroundCitric acid, a commodity product of industrial biotechnology, is produced by fermentation of the filamentous fungus Aspergillus niger. A requirement for high-yield citric acid production is keeping the concentration of Mn

resultswe identified an A. niger gene (dmtA; NRRL3_07789), predicted to encode a transmembrane protein, with high sequence identity to the yeast manganese transporters Smf1p and Smf2p. Deletion of dmtA in A. niger eliminated the intake of Mn

conclusionsOur results demonstrate that dmtA is physiologically important in the transport of Mn

Indexed as

Aspergillus nigerBiotechnologyCitric AcidFermentationFungal ProteinsLoss of Function MutationManganeseMethyltransferasesCitric AcidFungal ProteinsManganeseMethyltransferasesomtA protein, AspergillusAspergillus nigerCitric acidManganese ionsManganese transporter

Identifiers

PMID32000778
PMCPMC6993379
OpenAlexW3003941521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.