ArticleBMC oral health2020
Vitamin D receptor genetic polymorphisms are associated with oral lichen planus susceptibility in a Chinese Han population.
Article in BMC oral health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis.Frontiers in oral health · 2025Pooled it
- Role of Vitamin D and Vitamin D Receptor in Oral Lichen Planus: A Systematic Review.Ethiopian journal of health sciences · 2020Pooled it
- Treatments in oral lichen planus: a review.Frontiers in oral health · 2026Review
- VDR polymorphisms and their influence on oral squamous cell carcinoma susceptibility: a systematic review.Frontiers in oral health · 2026Review
- Oral Lichen Planus: A Narrative Review Navigating Etiologies, Clinical Manifestations, Diagnostics, and Therapeutic Approaches.Journal of clinical medicine · 2024Review
- Association between Vitamin D Receptor Polymorphism and Susceptibility to Oral Lichen Planus and Oral Squamous Cell Carcinoma.Iranian journal of otorhinolaryngology · 2024Article
- Serum Concentration of Vitamin D in Patients with Oral Lichen Planus.Acta stomatologica Croatica · 2023Article
- Disturbed expression of vitamin D and retinoic acid-related orphan receptors α and γ and of megalin in inflammatory skin diseases.Experimental dermatology · 2022Article
- Rise and exacerbation of oral lichen planus in the background of SARS-CoV-2 infection.Medical hypotheses · 2021Article
- Article
- MicroRNA-122 promotes apoptosis of keratinocytes in oral lichen planus through suppressing VDR expression.Journal of cellular and molecular medicine · 2021Article
- Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundVitamin D receptor (VDR) is involved in multiple immune-mediated disorders including oral lichen planus (OLP). This study investigated the association between VDR gene polymorphisms and the risk of OLP.
methodsIn total, 177 OLP patients and 207 healthy participants were recruited from the Affiliated Hospital of Stomatology, Nanjing Medical University. Eight single nucleotide polymorphisms (SNPs: rs731236, rs739837, rs757343, rs2107301, rs2239185, rs7975232, rs11574129 and rs11568820) in the VDR gene were selected and genotyped.
resultsThe results showed that OLP risk was increased in subjects with the rs2239185 TT genotype (Recessive model: adjusted Odd ratio(OR) = 2.68, 95% Confidence interval(CI) = 1.28-5.62, P = 0.009) and rs7975232 CC genotype (Recessive model: adjusted OR = 2.25, 95% CI = 1.10-4.58, P = 0.026). Moreover, rs2239185 and rs7975232 (P < 0.01) showed significant cumulative effects on OLP risk.Haplotype analysis showed that the CC haplotype (rs2239185-rs7975232) was associated with an increased risk of OLP (OR = 3.11, 95% CI = 1.42-6.83, P = 0.005), compared with the AC haplotype.
conclusionThe rs2239185 and rs7975232 variants of VDR may influence OLP susceptibility, and VDR gene polymorphisms may be candidate susceptibility regions for OLP in a Chinese Han population.
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