ArticleBMC nephrology2020
MEST-C pathological score and long-term outcomes of child and adult patients with Henoch-Schönlein purpura nephritis.
Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Predictability of the Oxford classification of IgA nephropathy in Henoch-Schonlein purpura nephritis.International urology and nephrology · 2022Pooled it
- An individualized prognostic nomogram integrating clinical and pathological features in pediatric IgA vasculitis nephritis.Frontiers in medicine · 2026Article
- Efficacy and safety of telitacicept in children with IgA vasculitis and IgA vasculitis nephritis: a single-center retrospective study.Pediatric rheumatology online journal · 2025Observational
- Identification of risk factors for renal progression in adults with IgAV: a retrospective cohort study of a single center in northwest China.International urology and nephrology · 2025Article
- Comprehensive analysis of the clinical and pathological features and prognoses of children with immunoglobulin A vasculitis nephritis with immunoglobulin M deposits in glomeruli.Kidney research and clinical practice · 2025Article
- Disease Course and Long-Term Outcomes in Adult IgA Vasculitis Nephritis: A Prospective Observational Study.Diagnostics (Basel, Switzerland) · 2025Article
- Biomarker research for Henoch-Schönlein purpura nephritis based on "omics" techniques.Frontiers in medicine · 2025Review
- [Urinary protein and renal pathological features in children with immunoglobulin A vasculitis with nephritis and hypercoagulability].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Bowman's capsule rupture and the Oxford MEST-C score in adult patients with Immunoglobulin a vasculitis nephritis: a single center experience.Annals of medicine · 2023Article
- Comparative study on clinicopathological features and prognosis of IgA vasculitis nephritis and IgA nephropathy in children.BMC pediatrics · 2023Article
- Semiquantitative classification (SQC) and Oxford classifications predict poor renal outcome better than The International Study of Kidney Disease in Children (ISKDC) and Haas in patients with IgAV nephritis: a multicenter study.Journal of nephrology · 2023Article
- Comparison of clinical, pathological and long-term renal outcomes of children with Henoch-Schonlein purpura nephritis and IgA nephropathy.International urology and nephrology · 2022Article
- A retrospective study on the characteristics of renal pathological grades in HSPN children with mild to moderate proteinuria.Frontiers in pediatrics · 2022Article
- Epidemiology of biopsy-proven Henoch-Schönlein purpura nephritis in children: A nationwide survey in Japan.PloS one · 2022Article
- IgA vasculitis nephritis in children and adults: one or different entities?Pediatric nephrology (Berlin, Germany) · 2021Review
- IgA Vasculitis in Adults: a Rare yet Challenging Disease.Current rheumatology reports · 2021Review
- Using MEST-C Scores and the International Study of Kidney Disease in Children Classification to Predict Outcomes of Henoch-Schönlein Purpura Nephritis in Children.Frontiers in pediatrics · 2021Article
- Influence of transitional nursing on the compliance behavior and disease knowledge of children with purpura nephritis.World journal of clinical cases · 2020Article
- Global Glomerulosclerosis and Segmental Glomerulosclerosis Could Serve as Effective Markers for Prognosis and Treatment of IgA Vasculitis With Nephritis.Frontiers in medicine · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundHenoch-Schönlein purpura nephritis (HSPN), a small-vessel vasculitis, shares renal pathological features with immunoglobulin A nephropathy. Oxford classification of immunoglobulin A nephropathy pathology has been updated to the MEST-C score, but its application in HSPN remains unresolved.
methodsTwo hundred and thirteen patients with biopsy-proven HSPN were retrieved from the Seoul National University Hospital between 2000 and 2017. Renal outcome risks (i.e., end-stage renal disease or doubling of serum creatinine) were evaluated according to MEST-C scores after stratification by age: 113 children aged < 18 years (9.2 ± 3.6 years) and 100 adults aged ≥18 years (38.6 ± 18.3 years). We pooled our data with four previous cohort studies in which MEST or MEST-C scores were described in detail.
resultsTwenty-one child (19%) and 16 adult (16%) patients reached the renal outcome during the median follow-up periods of 12 years and 13 years, respectively (maximum 19 years). In children, M1 and T1/T2 scores revealed worse renal outcomes than did M0 and T0 scores, respectively, whereas the T score was the only factor related to worse outcomes in adult patients after adjusting for multiple clinical and laboratory variables. The pooled data showed that M1, S1, and T1/T2 in children and E1 and T1/T2 in adults were correlated with poorer renal outcomes than those of their counterpart scores.
conclusionsThe Oxford classification MEST-C scores can predict long-term renal outcomes in patients with HSPN.
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