Evidence map›Paper›PMID 32000627›Full record

ArticleTissue engineering. Part A2020

Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model.

Dominique R Smith, Courtney M Dumont, Jonghyuck Park, Andrew J Ciciriello, Amina Guo, Ravindra Tatineni, Brian J Cummings, Aileen J Anderson, Lonnie D Shea

Open access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Nanoparticle and epothilone D combinatorial intervention improves motor performance and regeneration in chronic cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Role of dendritic cells in spinal cord injury.CNS neuroscience & therapeutics · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Neuroprotective effects of interleukin 10 in spinal cord injury.Frontiers in molecular neuroscience · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Dominique R SmithDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Courtney M DumontDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Jonghyuck ParkDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky.
Andrew J CicirielloDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Amina GuoDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Ravindra TatineniDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Brian J CummingsInstitute for Memory Impairments and Neurological Disorders (iMIND), University of California, Irvine, California.
Aileen J AndersonInstitute for Memory Impairments and Neurological Disorders (iMIND), University of California, Irvine, California.
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
University of Michigan–Ann Arbor · USUniversity of California, Irvine · USUniversity of Kentucky · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge. The complex, dynamic, inhibitory microenvironment postinjury, which is characterized by proinflammatory signaling from invading leukocytes and lack of sufficient factors that promote axonal survival and elongation, limits regeneration. Herein, we investigated the delivery of polycistronic vectors, which have the potential to coexpress factors that target distinct barriers to regeneration, from a multiple channel poly(lactide-

Indexed as

AnimalsBlotting, WesternFemaleImmunohistochemistryInterleukin-10LocomotionMiceMice, Inbred C57BLMyelin SheathNerve Growth FactorsNerve RegenerationOligodendrogliaReceptor, EphB3Spinal Cord InjuriesInterleukin-10Nerve Growth Factorsneurotropin 3, mouseReceptor, EphB3axon elongationaxon myelinationbiomaterialgene therapyspinal cord injury

Identifiers

PMID32000627
PMCPMC7310216
OpenAlexW3004141272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.