Evidence map›Paper›PMID 32000019›Full record

ArticleRedox biology2020

Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss.

Francis Rousset, German Nacher-Soler, Marta Coelho, Sten Ilmjarv, Vivianne Beatrix Christina Kokje, Antoine Marteyn, Yves Cambet, Michael Perny, Marta Roccio, Vincent Jaquet and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  5. Nox3 expression and function in retinal ganglion cells and Amacrine cells.Cellular and molecular life sciences : CMLS · 2025
    Article
  6. Review
  7. Article
  8. Article
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  10. TheBiomolecules · 2025
    Review
  11. Review
  12. Review
  13. NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Francis RoussetHearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland. Electronic address: Francis.Rousset@unige.ch.
German Nacher-SolerHearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.
Marta CoelhoHearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.
Sten IlmjarvDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.
Vivianne Beatrix Christina KokjeHearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.
Antoine MarteynDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.
Yves CambetDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland; READS Unit, Faculty of Medicine, University of Geneva, Switzerland.
Michael PernyDepartment of Biomedical Research (DBMR), University of Bern, Switzerland; Department of Otorhinolaryngology, Inselspital Bern, Switzerland.
Marta RoccioDepartment of Biomedical Research (DBMR), University of Bern, Switzerland; Department of Otorhinolaryngology, Inselspital Bern, Switzerland.
Vincent JaquetDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland; READS Unit, Faculty of Medicine, University of Geneva, Switzerland.
Pascal SennHearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland; Department of Clinical Neurosciences, Service of ORL & Head and Neck Surgery, University Hospital of Geneva, Switzerland.
Karl Heinz KrauseDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.
University of Geneva · CHUniversity Hospital of Bern · CHUniversity Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related hearing (ARHL) loss affects a large part of the human population with a major impact on our aging societies. Yet, underlying mechanisms are not understood, and no validated therapy or prevention exists. NADPH oxidases (NOX), are important sources of reactive oxygen species (ROS) in the cochlea and might therefore be involved in the pathogenesis of ARHL. Here we investigate ARHL in a mouse model. Wild type mice showed early loss of hearing and cochlear integrity, while animals deficient in the NOX subunit p22

Indexed as

Gene Regulatory NetworksAnimalsCells, CulturedDisease Models, AnimalFemaleHair Cells, AuditoryHumansMaleMiceNADPH OxidasesOxidation-ReductionPresbycusisReactive Oxygen SpeciesUp-RegulationCYBA protein, humanNADPH OxidasesReactive Oxygen SpeciesAge-related hearing lossAuditory neuronsExcitotoxicityGlutamatergic signalingNADPH oxidasePresbycusis

Identifiers

PMID32000019
PMCPMC7016250
OpenAlexW3002358416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.