ArticleClinical and experimental pediatrics2020
High-flow nasal cannula oxygen therapy in children: a clinical review.
Article in Clinical and experimental pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Pooled it
- High-flow nasal cannula versus continuous positive airway pressure for noninvasive respiratory support in children with bronchiolitis: a meta-analysis of randomized controlled trials.Frontiers in pediatrics · 2026Pooled it
- Guideline
- 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 6. Pediatric basic life support.Clinical and experimental emergency medicine · 2021Guideline
- Oxygen therapy for children with an oxygen saturation of 90-93% in Malawi: the NoGoLOBMJ paediatrics open · 2026Trial
- Comparison of Two Weaning Methods from Heated Humidified High-Flow Nasal Cannula Therapy in Pediatric Intensive Care Unit.Pediatric allergy, immunology, and pulmonology · 2022Trial
- Vibrating Mesh Nebulizer (A-VMN) Performance During Low-Flow Nasal Oxygen Therapy in Neonates.Pharmaceutics · 2026Article
- High-flow nasal cannula use for respiratory support in children for indications other than acute bronchiolitis.The Cochrane database of systematic reviews · 2026Article
- Review
- Subcutaneous emphysema as a complication of measles: A case series of nine pediatric patients from Ethiopia.IDCases · 2026Article
- Tools for Monitoring Respiratory Distress in Heated Humidified High-flow Nasal Cannula in Children: How do We Score the Scores?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Acute Care of Patients with Moderate Respiratory Distress: Recommendations from an American College of Emergency Physicians Expert Panel.The western journal of emergency medicine · 2025Article
- Epidemiologic evaluation of pediatric patients receiving high-flow nasal cannula therapy in the pediatric emergency department.Medicine · 2025Observational
- High-flow nasal cannula oxygen therapy: physiological basis and clinical applications in anesthesia.Frontiers in medicine · 2025Review
- A matched analysis of the use of high flow nasal cannula for pediatric severe acute asthma.Pediatric pulmonology · 2024Article
- Review
- Respiratory Rate Oxygenation (ROX) index as predictor of high flow nasal cannula in pediatric patients in pediatric intensive care unit.BMC pulmonary medicine · 2024Article
- Comparison of the Efficacies of High-Flow Nasal Cannula Oxygen Therapy and Non-invasive Nasal Cannula Ventilation in Preventing Intubation.Turkish archives of pediatrics · 2024Article
- Two Extremely Preterm Infants Discharged with a Home High-Flow Nasal Cannula for Severe Bronchopulmonary Dysplasia.Case reports in pediatrics · 2024Article
- Associations With Severe Desaturation Events Among Children Receiving Noninvasive Respiratory Support at Time of Intubation.Respiratory care · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-flow nasal cannula (HFNC) is a relatively safe and effective noninvasive ventilation method that was recently accepted as a treatment option for acute respiratory support before endotracheal intubation or invasive ventilation. The action mechanism of HFNC includes a decrease in nasopharyngeal resistance, washout of dead space, reduction in inflow of ambient air, and an increase in airway pressure. In preterm infants, HFNC can be used to prevent reintubation and initial noninvasive respiratory support after birth. In children, flow level adjustments are crucial considering their maximal efficacy and complications. Randomized controlled studies suggest that HFNC can be used in cases of moderate to severe bronchiolitis upon initial low-flow oxygen failure. HFNC can also reduce intubation and mechanical ventilation in children with respiratory failure. Several observational studies have shown that HFNC can be beneficial in acute asthma and other respiratory distress. Multicenter randomized studies are warranted to determine the feasibility and adherence of HFNC and continuous positive airway pressure in pediatric intensive care units. The development of clinical guidelines for HFNC, including flow settings, indications, and contraindications, device management, efficacy identification, and safety issues are needed, particularly in children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.