ArticleBiosensors & bioelectronics2020
Passive and wireless, implantable glucose sensing with phenylboronic acid hydrogel-interlayer RF resonators.
Article in Biosensors & bioelectronics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Portable and label-free optical detection of sweat glucose using functionalized plasmonic nanopillar array.Microsystems & nanoengineering · 2026Article
- Biodegradable Implantable Electronics with Wireless Technology for Real-Time Clinical Applications.Advanced healthcare materials · 2026Review
- Material-driven glucose responsiveness in insulin delivery systems: carrier selection and performance.Frontiers in endocrinology · 2026Review
- Smart self-healing hydrogel wound dressings for diabetic wound treatment.Nanomedicine (London, England) · 2025Review
- Advancements in Passive Wireless Sensing Systems in Monitoring Harsh Environment and Healthcare Applications.Nano-micro letters · 2025Review
- Implantable Passive Sensors for Biomedical Applications.Sensors (Basel, Switzerland) · 2024Review
- Review
- Rapid and on-site wireless immunoassay of respiratory virus aerosols via hydrogel-modulated resonators.Nature communications · 2024Article
- Smart Hydrogel Swelling State Detection Based on a Power-Transfer Transduction Principle.ACS applied polymer materials · 2024Article
- Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage.Science advances · 2024Article
- Nanocomposite Hydrogel-Based Optical Fiber Probe for Continuous Glucose Sensing.Small science · 2024Article
- Design Strategies and Application Potential of Multifunctional Hydrogels for Promoting Angiogenesis.International journal of nanomedicine · 2024Review
- Advancements in Passive Wireless Sensors, Materials, Devices, and Applications.Sensors (Basel, Switzerland) · 2023Review
- Physics-Based Circuit Modeling of the Impedance Characteristics of a Smart Hydrogel-Actuated Bending Sensor.Sensors and actuators. A, Physical · 2022Article
- Enhanced terahertz sensitivity for glucose detection with a hydrogel platform embedded with Au nanoparticles.Biomedical optics express · 2022Article
- Article
- Glucose-to-Resistor Transduction Integrated into a Radio-Frequency Antenna for Chip-less and Battery-less Wireless Sensing.ACS sensors · 2022Article
- Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Hydrogel-based holographic sensors and biosensors: past, present, and future.Analytical and bioanalytical chemistry · 2022Review
- Permittivity-Inspired Microwave Resonator-Based Biosensor Based on Integrated Passive Device Technology for Glucose Identification.Biosensors · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A phenylboronic acid-based, hydrogel-interlayer Radio-Frequency (RF) resonator is demonstrated as a highly-responsive, passive and wireless sensor for glucose monitoring. Constructs are composed of unanchored, capacitively-coupled split rings interceded by glucose-responsive hydrogels. Phenylboronic acid-hydrogels exhibit volumetric and dielectric variations in response to environmental glucose concentrations-these are efficiently converted to large shifts in the resonant response of interlayer-RF sensors. These tiny, stretchable and scalable sensors (5 mm × 5 mm x 250 μm) require no microelectronics or power at the sensing node and can be read-out remotely via near-field coupling. Sensors exhibit high sensitivities (~10% shift in resonant frequency-corresponding to 50 MHz-per 150 mg/dL of glucose), possess a limit of detection of 10 mg/dL, and a step response time of approximately 1 h to abrupt shifts in carbohydrate concentration. Notably, these sensors exhibited no signal drift or hysteresis over the time periods characterized herein (45 days at room temperature). We transform sensors into bioelectronic RF reporter-tags via the attachment of a single LED-these remotely report on glucose concentration via emitted light. We anticipate the non-degradative, long-term nature of both RF read-out and phenylboronic acid-based hydrogels will enable biosensors capable of long-term, remote read-out of glucose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.