Evidence map›Paper›PMID 31999537›Full record

ReviewCirculation research2020

The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications.

David A Eisner, Jessica L Caldwell, Andrew W Trafford, David C Hutchings

Abstract readReview
In one paragraph

Review in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. RBM20 variants disrupt CaSignal transduction and targeted therapy · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
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  13. Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Ryanodine receptor stabilization therapy suppresses CaJournal of molecular and cellular cardiology · 2024
    Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David A EisnerFrom the Unit of Cardiac Physiology, Division of Cardiovascular Sciences, University of Manchester, United Kingdom.
Jessica L CaldwellFrom the Unit of Cardiac Physiology, Division of Cardiovascular Sciences, University of Manchester, United Kingdom.
Andrew W TraffordFrom the Unit of Cardiac Physiology, Division of Cardiovascular Sciences, University of Manchester, United Kingdom.
David C HutchingsFrom the Unit of Cardiac Physiology, Division of Cardiovascular Sciences, University of Manchester, United Kingdom.

Funding

British Heart Foundation CH/2000004/12801British Heart Foundation FS/12/57/29717British Heart Foundation FS/15/28/31476British Heart Foundation FS/17/52/33113British Heart Foundation PG/11/16/28777
6 · The paper itself

Abstract

Normal cardiac function requires that intracellular Ca

Indexed as

Calcium SignalingDiastoleAnimalsHeart FailureHumansMyocardiumVentricular Functioncalciumdiastoleheart failuremyofibrilsstroke volume

Identifiers

PMID31999537
PMCPMC7004450

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.