Evidence map›Paper›PMID 31999511›Full record

ReviewMolecular biology of the cell2020

Cellular self-organization: generating order from the abyss.

Derek McCusker

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Polarization as a Process: The Potential of Process Ontology for Understanding Cellular Symmetry Breaking.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Article
  4. A self-organizing single-cell morphology circuit optimizesbioRxiv : the preprint server for biology · 2025
    Article
  5. The QBIT Theory of Consciousness: Information, Correlation, and Coherence.Integrative psychological & behavioral science · 2024
    Article
  6. Osteoclasts at Bone Remodeling: Order from Order.Results and problems in cell differentiation · 2024
    Review
  7. Article
  8. Design principles of Cdr2 node patterns in fission yeast cells.bioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Derek McCuskerDynamics of Cell Growth and Division, European Institute of Chemistry and Biology, F-33607 Bordeaux, France; Institute of Biochemistry and Cellular Genetics, UMR 5095, University of Bordeaux and Centre National de la Recherche Scientifique, F-33000 Bordeaux, France.
Université de Bordeaux · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the organization of inanimate systems such as gases or liquids is predominantly thermodynamically driven-a mixture of two gases will tend to mix until they reach equilibrium-biological systems frequently exhibit organization that is far from a well-mixed equilibrium. The anisotropies displayed by cells are evident in some of the dynamic processes that constitute life including cell development, movement, and division. These anisotropies operate at different length-scales, from the meso- to the nanoscale, and are proposed to reflect self-organization, a characteristic of living systems that is becoming accessible to reconstitution from purified components, and thus a more thorough understanding. Here, some examples of self-organization underlying cellular anisotropies at the cellular level are reviewed, with an emphasis on Rho-family GTPases operating at the plasma membrane. Given the technical challenges of studying these dynamic proteins, some of the successful approaches that are being employed to study their self-organization will also be considered.

Indexed as

AnisotropyActinsAnimalsCell MembraneCell Physiological PhenomenaCellsGTP PhosphohydrolasesHumansLipid MetabolismLipidsrho GTP-Binding ProteinsThermodynamicsActinsGTP PhosphohydrolasesLipidsrho GTP-Binding Proteins

Identifiers

PMID31999511
PMCPMC7001480
OpenAlexW3005537723

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.