ArticleThe Journal of infectious diseases2020
Inhibition of Amebic Cysteine Proteases Blocks Amebic Trogocytosis but Not Phagocytosis.
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Preventing trogocytosis by cathepsin B inhibition augments CAR T-cell function.Signal transduction and targeted therapy · 2026Article
- Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function.bioRxiv : the preprint server for biology · 2025Article
- Intercellular Transfer of Immune Regulatory Molecules Via Trogocytosis.Results and problems in cell differentiation · 2024Review
- Extracellular Cysteine Proteases of Key Intestinal Protozoan Pathogens-Factors Linked to Virulence and Pathogenicity.International journal of molecular sciences · 2023Review
- Article
- Gnawing Between Cells and Cells in the Immune System: Friend or Foe? A Review of Trogocytosis.Frontiers in immunology · 2022Review
- The IL-33-ILC2 pathway protects from amebic colitis.Mucosal immunology · 2022Article
- Trogocytosis in Unicellular Eukaryotes.Cells · 2021Review
- Review
- Host Protective Mechanisms to Intestinal Amebiasis.Trends in parasitology · 2021Review
- The Multiple Roles of Trogocytosis in Immunity, the Nervous System, and Development.BioMed research international · 2021Review
- Taxon-Specific Proteins of the PathogenicFrontiers in cellular and infection microbiology · 2021Review
- Neutrophil interactions with the sexually transmitted parasiteOpen biology · 2020Review
- Biting Off What Can Be Chewed: Trogocytosis in Health, Infection, and Disease.Infection and immunity · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEntamoeba histolytica kills human cells by ingesting fragments of live cells until the cell eventually dies, a process termed amebic trogocytosis. In a previous study, we showed that acidified amebic lysosomes are required for both amebic trogocytosis and phagocytosis, as well as cell killing.
methodsAmebic cysteine proteases (CPs) were inhibited using an irreversible inhibitor, E-64d.
resultsInterfering with amebic CPs decreased amebic trogocytosis and amebic cytotoxicity but did not impair phagocytosis.
conclusionsWe show that amebic CPs are required for amebic trogocytosis and cell killing but not phagocytosis. These data suggest that amebic CPs play a distinct role in amebic trogocytosis and cell killing.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.