Evidence map›Paper›PMID 31999253›Full record

ArticleeLife2020

Quantitative analysis of 1300-nm three-photon calcium imaging in the mouse brain.

Tianyu Wang, Chunyan Wu, Dimitre G Ouzounov, Wenchao Gu, Fei Xia, Minsu Kim, Xusan Yang, Melissa R Warden, Chris Xu

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 130 citations in OpenAlex.

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  6. OPTRACE: Optical Imaging-Guided Transplantation and Tracking of Cells in the Mouse Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tianyu Wang *School of Applied and Engineering Physics, Cornell University, Ithaca, United States.ORCID 0000-0002-6087-6376
Chunyan Wu *School of Applied and Engineering Physics, Cornell University, Ithaca, United States.ORCID 0000-0002-6294-4512
Dimitre G OuzounovSchool of Applied and Engineering Physics, Cornell University, Ithaca, United States.
Wenchao GuDepartment of Neurobiology and Behavior, Cornell University, Ithaca, United States.
Fei XiaMeining School of Biomedical Engineering, Cornell University, Ithaca, United States.ORCID 0000-0001-6591-8769
Minsu KimCollege of Human Ecology, Cornell University, Ithaca, United States.
Xusan YangSchool of Applied and Engineering Physics, Cornell University, Ithaca, United States.
Melissa R WardenDepartment of Neurobiology and Behavior, Cornell University, Ithaca, United States.ORCID 0000-0003-2240-3997
Chris XuSchool of Applied and Engineering Physics, Cornell University, Ithaca, United States.ORCID 0000-0002-3493-6427
Cornell University · US

Funding

Imaging the Evolving Neural Circuit Dynamics of DepressionDP2MH109982 · NIMH · CORNELL UNIVERSITY · PI WARDEN, MELISSA RHOADS · 2015 to 2015
$2.3M
Intelligence Advanced Research Projects Activity D16PC00003National Science Foundation DBI-1707312NIMH NIH HHS DP2 MH109982
6 · The paper itself

Abstract

1300 nm three-photon calcium imaging has emerged as a useful technique to allow calcium imaging in deep brain regions. Application to large-scale neural activity imaging entails a careful balance between recording fidelity and perturbation to the sample. We calculated and experimentally verified the excitation pulse energy to achieve

Indexed as

AnimalsBrainCalciumMiceMice, TransgenicMicroscopy, Fluorescence, MultiphotonMonte Carlo MethodNeuronsPhotonsCalcium2-photon3-photoncalciummolecular biophysicsmouseneural imagingneurosciencestructural biologythree-photontwo-photon

Identifiers

PMID31999253
PMCPMC7028383
OpenAlexW3003688083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.