ArticleThe Analyst2020
Electroenzymatic glutamate sensing at near the theoretical performance limit.
Article in The Analyst, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Enzyme-modified microelectrodes for measurement of glutamate: Characterization and applications.Electroanalysis · 2025Article
- Enzyme-Mediated Organic Neurohybrid Synapses.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Integration of Glutamate Dehydrogenase and Nanoporous Gold for Electrochemical Detection of Glutamate.Biosensors · 2023Article
- Microcontact printing of choline oxidase using a polycation-functionalized zwitterionic polymer as enzyme immobilization matrix.The Analyst · 2023Article
- Accelerating the development of implantable neurochemical biosensors by using existing clinically applied depth electrodes.Analytical and bioanalytical chemistry · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The sensitivity and response time of glutamate sensors based on glutamate oxidase immobilized on planar platinum microelectrodes have been improved to near the theoretical performance limits predicted by a detailed mathematical model. Microprobes with an array of electroenzymatic sensing sites have emerged as useful tools for the monitoring of glutamate and other neurotransmitters in vivo; and implemented as such, they can be used to study many complex neurological diseases and disorders including Parkinson's disease and drug addiction. However, less than optimal sensitivity and response time has limited the spatiotemporal resolution of these promising research tools. A mathematical model has guided systematic improvement of an electroenzymatic glutamate microsensor constructed with a 1-2 μm-thick crosslinked glutamate oxidase layer and underlying permselective coating of polyphenylenediamine and Nafion reduced to less than 200 nm thick. These design modifications led to a nearly 6-fold improvement in sensitivity to 320 ± 20 nA μM
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Registered trials
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