ArticleScience advances2020
Triangular correlation (TrC) between cancer aggressiveness, cell uptake capability, and cell deformability.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Colloid-patterned surfaces distinguish malignant mechanophenotypes.Materials today. Bio · 2026Article
- Elasticity-Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- CDK4 as a Prognostic Marker of Hepatocellular Carcinoma and CDK4 Inhibitors as Potential Therapeutics.Current medicinal chemistry · 2025Article
- Elongated Particles Show a Preferential Uptake in Invasive Cancer Cells.Nanomaterials (Basel, Switzerland) · 2024Article
- Particle uptake in cancer cells can predict malignancy and drug resistance using machine learning.Science advances · 2024Article
- An injectable in situ hydrogel platform for sustained drug release against Glioblastoma.Journal of drug delivery science and technology · 2024Article
- Truncated PD1 Engineered Gas-Producing Extracellular Vesicles for Ultrasound Imaging and Subsequent Degradation of PDL1 in Tumor Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Analyzing force measurements of multi-cellular clusters comprising indeterminate geometries.Biomechanics and modeling in mechanobiology · 2024Article
- A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine.Communications biology · 2023Article
- Surface physical cues mediate the uptake of foreign particles by cancer cells.APL bioengineering · 2023Article
- Application of self-organizing maps to AFM-based viscoelastic characterization of breast cancer cell mechanics.Scientific reports · 2023Article
- Determining Spatial Variability of Elastic Properties for Biological Samples Using AFM.Micromachines · 2023Review
- The relationship between cancer and biomechanics.Frontiers in oncology · 2023Review
- Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers.Frontiers in oncology · 2023Review
- The aspect ratio effect on the cytotoxicity of inert nano-particles flips depending on particle thickness, and is one of the reasons for the literature inconsistency.Nanoscale advances · 2022Article
- Review
- Upregulated LINC00922 Promotes Epithelial-Mesenchymal Transition and Indicates a Dismal Prognosis in Gastric Cancer.Journal of oncology · 2022Article
- Enhanced Biomechanically Mediated "Phagocytosis" in Detached Tumor Cells.Biomedicines · 2021Article
- The Biological and Biomechanical Role of Transglutaminase-2 in the Tumour Microenvironment.Cancers · 2021Review
- Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors.Nature immunology · 2021Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
The malignancy potential is correlated with the mechanical deformability of the cancer cells. However, mechanical tests for clinical applications are limited. We present here a Triangular Correlation (TrC) between cell deformability, phagocytic capacity, and cancer aggressiveness, suggesting that phagocytic measurements can be a mechanical surrogate marker of malignancy. The TrC was proved in human prostate cancer cells with different malignancy potential, and in human bladder cancer and melanoma cells that were sorted into subpopulations based solely on their phagocytic capacity. The more phagocytic subpopulations showed elevated aggressiveness ex vivo and in vivo. The uptake potential was preserved, and differences in gene expression and in epigenetic signature were detected. In all cases, enhanced phagocytic and aggressiveness phenotypes were correlated with greater cell deformability and predicted by a computational model. Our multidisciplinary study provides the proof of concept that phagocytic measurements can be applied for cancer diagnostics and precision medicine.
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