Evidence map›Paper›PMID 31998707›Full record

ArticleFrontiers in bioengineering and biotechnology2019

Mutagenesis-Based Characterization and Improvement of a Novel Inclusion Body Tag.

Wouter S P Jong, Corinne M Ten Hagen-Jongman, David Vikström, Wendy Dontje, Abdallah M Abdallah, Jan-Willem de Gier, Wilbert Bitter, Joen Luirink

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Coiled-Coil Based Inclusion Bodies and Their Potential Applications.Frontiers in bioengineering and biotechnology · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 4 countries.

Wouter S P JongAbera Bioscience AB, Solna, Sweden.
Corinne M Ten Hagen-JongmanDepartment of Molecular Microbiology, Amsterdam Institute for Molecules Medicines and Systems (AIMMS), Vrije Universiteit, Amsterdam, Netherlands.
David VikströmXbrane Biopharma AB, Solna, Sweden.
Wendy DontjeDepartment of Clinical Immunology and Rheumatology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Abdallah M AbdallahDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.
Jan-Willem de GierDepartment of Biochemistry and Biophysics, Center for Biomembrane Research, Stockholm University, Stockholm, Sweden.
Wilbert BitterDepartment of Molecular Microbiology, Amsterdam Institute for Molecules Medicines and Systems (AIMMS), Vrije Universiteit, Amsterdam, Netherlands.
Joen LuirinkAbera Bioscience AB, Solna, Sweden.
Vrije Universiteit Amsterdam · NLAbera Bioscience (Sweden) · SEAmsterdam University Medical Centers · NLQatar University · QAStockholm University · SEUniversity of Amsterdam · NLXbrane Biopharma (Sweden) · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whereas, bacterial inclusion bodies (IBs) for long were regarded as undesirable aggregates emerging during recombinant protein production, they currently receive attention as promising nanoparticulate biomaterials with diverse applications in biotechnology and biomedicine. We previously identified ssTorA, a signal sequence that normally directs protein export via the Tat pathway in

Indexed as

chaperonefusion tagheterologous protein productioninclusion bodiesinsoluble expressionprotein aggregationsignal peptidetwin-arginine translocation pathway

Identifiers

PMID31998707
PMCPMC6965018
OpenAlexW3000129304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.