Evidence map›Paper›PMID 31998692›Full record

ArticleFrontiers in chemistry2019

Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies-Activities Against Blood Stage

Ho Ning Wong, Vivian Padín-Irizarry, Mariëtte E van der Watt, Janette Reader, Wilna Liebenberg, Lubbe Wiesner, Peter Smith, Korina Eribez, Elizabeth A Winzeler, Dennis E Kyle and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Review
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  11. Review
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  13. First principle study of silver nanoparticle interactions with antimalarial drugs extracted fromJournal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ho Ning WongCentre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Vivian Padín-IrizarryCenter for Tropical & Emerging Global Diseases, Coverdell Center, University of Georgia, Athens, GA, United States.
Mariëtte E van der WattMalaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.
Janette ReaderMalaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.
Wilna LiebenbergCentre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Lubbe WiesnerDivision of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Peter SmithDivision of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Korina EribezSchool of Medicine, University of California, San Diego, La Jolla, CA, United States.
Elizabeth A WinzelerSchool of Medicine, University of California, San Diego, La Jolla, CA, United States.
Dennis E KyleCenter for Tropical & Emerging Global Diseases, Coverdell Center, University of Georgia, Athens, GA, United States.
Lyn-Marie BirkholtzMalaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.
Dina CoertzenMalaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.
Richard K HaynesCentre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

Funding

Orally Bioavailable 4(1H)-Quinolones with Multi-Stage Antimalarial ActivityR01AI144464 · NIAID · NORTHEASTERN UNIVERSITY · PI KYLE, DENNIS E, MANETSCH, ROMAN · 2019 to 2023
$3.6M
6 · The paper itself

Abstract

We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives dihydroartemisinin (DHA), artemether and artesunate, display potent activities

Indexed as

amino-artemisininsgametocytesmalariasporozoitestransmission-blocking

Identifiers

PMID31998692
PMCPMC6967409

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.