Evidence map›Paper›PMID 31998474›Full record

ArticleAntimicrobial resistance and infection control2020

Spread of multidrug resistance among

Safa Boujemaa, Béhija Mlik, Amina Ben Allaya, Helmi Mardassi, Boutheina Ben Abdelmoumen Mardassi

Open access · goldAbstract read
In one paragraph

Article in Antimicrobial resistance and infection control, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  9. Clonal Spread of Tetracycline Resistance AmongInfection and drug resistance · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Safa BoujemaaGroup of Mycoplasmas, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, 13, Place Pasteur-B.P 74, 1002 Tunis-Belvédère, Tunisia.
Béhija MlikGroup of Mycoplasmas, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, 13, Place Pasteur-B.P 74, 1002 Tunis-Belvédère, Tunisia.
Amina Ben AllayaGroup of Mycoplasmas, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, 13, Place Pasteur-B.P 74, 1002 Tunis-Belvédère, Tunisia.
Helmi MardassiUnit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, 13, Place Pasteur-B.P 74, 1002 Tunis-Belvédère, Tunisia.
Boutheina Ben Abdelmoumen MardassiGroup of Mycoplasmas, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, 13, Place Pasteur-B.P 74, 1002 Tunis-Belvédère, Tunisia.
Institut Pasteur de Tunis · TNTunis El Manar University · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: This study included 101 molecularly typed Results: We found that all ureaplasma isolates were resistant to ciprofloxacin and erythromycin, intermediately resistant to azithromycin, and susceptible to doxycycline, moxifloxacin and josamycin. Ofloxacin and levofloxacin resistance was found in 73.27 and 17.82%, respectively, while 37.62% of isolates proved resistant to tetracycline. Consequently, we detected an elevated multidrug resistance rate among ureaplasma isolates (37.62%), particularly among serovars 2, 5, 8, and 9 (77.77% overall), as well as serovars 4, 10, 12, and 13 (52.63% overall). In most cases, drug resistance was found to be associated with known molecular mechanisms, yet we have identified two novel mutations in the L22 protein, which might be associated with macrolide-resistance. Conclusion: To our knowledge, this is the first study that reports the widespread expansion of multidrug resistance among

Indexed as

Drug Resistance, Multiple, BacterialMutationAnti-Bacterial AgentsAzithromycinBacterial ProteinsCiprofloxacinErythromycinFemaleHumansMaleMicrobial Sensitivity TestsPhylogenySerogroupTunisiaUreaplasmaUreaplasma InfectionsAnti-Bacterial AgentsAzithromycinBacterial ProteinsCiprofloxacinErythromycinBiotypingFluoroquinolonesInfertilityL22 mutationMultidrug resistanceSerovarsTetracyclinesUreaplasma spp.

Identifiers

PMID31998474
PMCPMC6979072
OpenAlexW3006674092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.