Evidence map›Paper›PMID 31998317›Full record

ArticleFrontiers in immunology2019

Apparent Lack of

Paul G Kemps, Timo C Zondag, Eline C Steenwijk, Quirine Andriessen, Jelske Borst, Sandra Vloemans, Dave L Roelen, Lenard M Voortman, Robert M Verdijk, Carel J M van Noesel and 17 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Innovative immunotherapeutic strategies for thyroid cancer: challenges and opportunities.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Review
  3. Review
  4. Immunotherapy for pediatric low-grade gliomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 6 institutions in 2 countries.

Paul G KempsImmunology Laboratory Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands.
Timo C ZondagDepartment of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.
Eline C SteenwijkImmunology Laboratory Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands.
Quirine AndriessenImmunology Laboratory Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands.
Jelske BorstImmunology Laboratory Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands.
Sandra VloemansDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Dave L RoelenDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Lenard M VoortmanDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
Robert M VerdijkDepartment of Pathology, Erasmus University Medical Center, Rotterdam, Netherlands.
Carel J M van NoeselDepartment of Pathology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Arjen H G ClevenDepartment of Pathology, Leiden University Medical Center, Leiden, Netherlands.
Cynthia HawkinsHospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Veronica LangHospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Arnoud H de RuCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.
George M C JanssenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.
Geert W HaasnootDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Kees L M C FrankenDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Ronald van EijkDepartment of Pathology, Leiden University Medical Center, Leiden, Netherlands.
Nienke Solleveld-WesterinkDepartment of Pathology, Leiden University Medical Center, Leiden, Netherlands.
Tom van WezelDepartment of Pathology, Leiden University Medical Center, Leiden, Netherlands.
R Maarten EgelerImmunology Laboratory Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands.
Auke BeishuizenDepartment of Pediatric Oncology, Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, Netherlands.
Jan A M van LaarDepartment of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.
Oussama AblaHospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Cor van den BosPrincess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Peter A van VeelenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.
Astrid G S van HalterenImmunology Laboratory Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands.
Leiden University Medical Center · NLErasmus MC · NLAmsterdam University Medical Centers · NLHospital for Sick Children · CANetherlands Metabolomics Centre · NLSickKids Foundation · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Langerhans Cell Histiocytosis (LCH) is a neoplastic disorder of hematopoietic origin characterized by inflammatory lesions containing clonal histiocytes (LCH-cells) intermixed with various immune cells, including T cells. In 50-60% of LCH-patients, the somatic

Indexed as

AdultAntigens, NeoplasmCD8-Positive T-LymphocytesCell Line, TumorChildFemaleHistiocytosis, Langerhans-CellHLA-A AntigensHumansMaleMutationNeoplasmsProto-Oncogene Proteins B-rafAntigens, NeoplasmBRAF protein, humanHLA-A AntigensProto-Oncogene Proteins B-rafBRAFHuman Leukocyte AntigenLangerhans Cell HistiocytosisneoantigenneopeptideT cell

Identifiers

PMID31998317
PMCPMC6967030
OpenAlexW2999946188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.