Evidence map›Paper›PMID 31998314›Full record

ArticleFrontiers in immunology2019

Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing.

Frederick J Goodson-Gregg, Brian Rothbard, Amy Zhang, Paul W Wright, Hongchuan Li, Victoria E Walker-Sperling, Mary Carrington, Stephen K Anderson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Frederick J Goodson-GreggCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States.
Brian RothbardCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States.
Amy ZhangCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States.
Paul W WrightBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Hongchuan LiBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Victoria E Walker-SperlingCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States.
Mary CarringtonBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Stephen K AndersonBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Center for Cancer Research · USFrederick National Laboratory for Cancer Research · USNational Cancer Institute · USRagon Institute of MGH, MIT and Harvard · US

Funding

NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

A complex system regulating HLA-C expression in NK cells, driven by an NK-specific promoter that produces alternatively spliced variants of the 5'-UTR has been recently identified. Exon content of the NK-specific 5'-UTR varies strikingly across

Indexed as

5' Untranslated RegionsAllelesAlternative SplicingCell LineDNA, ComplementaryExonsHLA-C AntigensHumansKiller Cells, NaturalRNA, Messenger5' Untranslated RegionsDNA, ComplementaryHLA-C AntigensRNA, Messengeralternative splicingHLA-ChumanNKNK-promoterpeptide loading

Identifiers

PMID31998314
PMCPMC6966967
OpenAlexW3000663835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.