ReviewFrontiers in psychiatry2019
Oxytocin as Treatment for Social Cognition, Not There Yet.
Review in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Oxytocin-enhanced group therapy for methamphetamine use disorder: Randomized controlled trial.Journal of substance abuse treatment · 2020Trial
- Dose-dependent anxiolytic and antidepressant-like effects of chronic oxytocin in corticosterone-induced female mouse model of anxiety and depression.Biochemistry and biophysics reports · 2026Article
- Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder.Journal of neurochemistry · 2026Review
- The Role of Pharmacotherapy in Social Cognition, Empathy, and Serum Oxytocin Levels in Children with Attention Deficit Hyperactivity Disorder: A Case-Control Study.Children (Basel, Switzerland) · 2025Article
- Effects of Intranasal Oxytocin Across Various Depressive Disorders.Psychiatry investigation · 2025Article
- Critical Windows: Exploring the Association Between Perinatal Trauma, Epigenetics, and Chronic Pain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- An evolutionary timeline of the oxytocin signaling pathway.Communications biology · 2024Article
- Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024Review
- Linking childhood trauma to the psychopathology of schizophrenia: the role of oxytocin.Schizophrenia (Heidelberg, Germany) · 2024Article
- Article
- Oxytocin as a physiological correlate of dyadic music therapy relationships - a randomized crossover pilot study.Frontiers in behavioral neuroscience · 2024Article
- Pharmacological Treatment of Cognitive Impairment Associated With Schizophrenia: State of the Art and Future Perspectives.Schizophrenia bulletin open · 2024Article
- The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain.Molecular brain · 2023Article
- Does activation of oxytocinergic reward circuits postpone the decline of the aging brain?Frontiers in psychology · 2023Review
- Oxytocin enhances basolateral amygdala activation and functional connectivity while processing emotional faces: preliminary findings in autistic vs non-autistic women.Social cognitive and affective neuroscience · 2022Article
- Combinatorial approaches for treating neuropsychiatric social impairment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Oxytocin does not stand alone.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Interplay between the oxytocin and opioid systems in regulating social behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Individual differences in the encoding of contextual details following acute stress: An explorative study.The European journal of neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a short time, oxytocin has progressed from being a regular hormone involved in parturition and breastfeeding to be possibly the neuromodulator that has gathered the most attention. Attributed many positive roles in the modulation of different aspects of social behavior, such as bonding, empathy, cooperation, trust, and generosity, as well as roles as a natural anxiolytic and antidepressant, the expectations on oxytocin becoming a treatment for a number of disorders with associated social deficits have dramatically raised over the last years. However, despite the field has been investigating oxytocin's role in social behavior for over twenty years, there are still many unknowns on oxytocin's mechanisms of action and efficiency and the increasing number of clinical trials administering oxytocin to different clinical groups seem to disagree in its properties and report in most cases conflicting results. This has led to some disappointment among researchers and clinicians as oxytocin might not be the miraculous molecule that works in a "one size fits all" fashion initially considered. Conversely, this down-side of oxytocin might merely reflect the complexity of its neurotransmission system. The current reality is that, although oxytocin seems to have potential therapeutic value, there are key questions that remain unanswered as to decide the optimal target groups and treatment course. Here, we present an overview on critical points regarding the oxytocin system in health and disease that need to be better understood to establish its therapeutic properties and to decide who could benefit the most from its treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.