ArticleFrontiers in systems neuroscience2019
Volume-Conducted Origin of the Field Potential at the Lateral Habenula.
Article in Frontiers in systems neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The habenula in mood disorders: A systematic review of human studies.Molecular psychiatry · 2025Pooled it
- Transdermal electrophysiological recordings of diet-induced small fiber peripheral neuropathy using a needle electrode array in mice and man.Frontiers in bioengineering and biotechnology · 2024Article
- Article
- Site-dependent shaping of field potential waveforms.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Visual cortical LFP in relation to the hippocampal theta rhythm in track running rats.Frontiers in cellular neuroscience · 2023Article
- Theoretical considerations and supporting evidence for the primary role of source geometry on field potential amplitude and spatial extent.Frontiers in cellular neuroscience · 2023Review
- Article
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Authors and funding
8 authors.
Funding
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Abstract
Field potentials (FPs) are easily reached signals that provide information about the brain's processing. However, FP should be interpreted cautiously since their biophysical bases are complex. The lateral habenula (LHb) is a brain structure involved in the encoding of aversive motivational values. Previous work indicates that the activity of the LHb is relevant for hippocampal-dependent learning. Moreover, it has been proposed that the interaction of the LHb with the hippocampal network is evidenced by the synchronization of LHb and hippocampal FPs during theta rhythm. However, the origin of the habenular FP has not been analyzed. Hence, its validity as a measurement of LHb activity has not been proven. In this work, we used electrophysiological recordings in anesthetized rats and feed-forward modeling to investigate biophysical basis of the FP recorded in the LHb. Our results indicate that the FP in the LHb during theta rhythm is a volume-conducted signal from the hippocampus. This result highlight that FPs must be thoroughly analyzed before its biological interpretation and argues against the use of the habenular FP signal as a readout of the activity of the LHb.
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